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Agent and method for treating disorders associated with cytidine deaminase or deoxycytidine deaminase overexpression

dc.contributor.authorNyce, Jonathan W.
dc.date.accessioned2016-02-05T17:01:21Z
dc.date.available2016-02-05T17:01:21Z
dc.date.issued2000-10-24
dc.description.abstractAn agent of the chemical formula C.sub.7 N.sub.3 H.sub.8 O.sub.2 R.sup.1 R.sup.2 XX.sup.1, wherein X and X.sup.1 are each independently C or N but not simultaneously, R.sup.1 is lower alkyl, alkenyl or alkynyl, halogen or haloalkyl, and R.sup.2 is H, --N.sub.3 --OH, amino or halogen; or pharmaceutically acceptable salts thereof. A method of treating a disorder associated with the overexpression of cytidine deaminase or deoxycytidine deaminase comprises administering to a subject in need of the treatment a compound of the chemical formula ##STR1## wherein X and X.sub.1 are each independently C or N; R.sup.1 is lower alkyl, lower alkenyl, lower alkynyl, halogen, or haloalkyl; and R.sup.2 H, --N.sub.3, --OH, amino, or halogen; or a pharmaceutically acceptable salt thereof in an amount effective to treat the disorder. Pharmaceutical formulations useful in the method of the present invention are also disclosed.en_US
dc.identifier.otherU.S. Patent No. 6,136,791
dc.identifier.urihttp://hdl.handle.net/10342/5175
dc.titleAgent and method for treating disorders associated with cytidine deaminase or deoxycytidine deaminase overexpressionen_US
dc.typePatenten_US

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