HuR involvement in mitotic clonal expansion during acquisition of the adipocyte phenotype

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dc.contributor.authorKarschner, Vesna Annen_US
dc.contributor.authorPekala, Phillip H.en_US
dc.date.accessioned2010-12-10T14:07:28Zen_US
dc.date.accessioned2011-05-17T01:27:04Z
dc.date.available2010-12-10T14:07:28Zen_US
dc.date.available2011-05-17T01:27:04Z
dc.date.issued2009-05-29en_US
dc.description.abstractIn the nucleus HuR binds to mRNAs containing adenylate-uridylate rich elements in the 3?- untranslated region. HuR may influence expression of its ligand mRNA through regulation of polyadenylation, translocation of the message to the cytosol, stabilization of the mRNA and/or altering its translational efficiency. Suppression of HuR using siRNA resulted in an attenuation of the 3T3-L1 differentiation program, consistent with HuR control of the expression of mRNA ligand (s) critical to the differentiation process. In the current study we begin to identify mRNA ligands of HuR whose regulated expression is necessary for adipogenesis. Originally published in Biochemical and Biophysiological Research Communications Vol. 383, No. 2 2009.en_US
dc.identifier.citationBiochemical and Biophysical Research Communications; 383:2 p. 203-205en_US
dc.identifier.doi10.1016/j.bbrc.2009.03.152
dc.identifier.pmidPMC2693087en_US
dc.identifier.urihttp://hdl.handle.net/10342/3026en_US
dc.language.isoen_USen_US
dc.publisherEast Carolina Universityen_US
dc.relation.urihttp://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WBK-4W0SJXH-7&_user=634873&_coverDate=05%2F29%2F2009&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000033758&_version=1&_urlVersion=0&_userid=634873&md5=33bac885d3c5d742e3a65cbe1ba906cd&searchtype=aen_US
dc.subjectAdipogenisisen_US
dc.subjectDifferentiationen_US
dc.subject3T3-L1en_US
dc.subjectHuRen_US
dc.subjectElaven_US
dc.subjectSiRNAen_US
dc.subjectβ-actinen_US
dc.subjectp53en_US
dc.subject[Beta]-actin
dc.titleHuR involvement in mitotic clonal expansion during acquisition of the adipocyte phenotypeen_US
dc.typeArticleen_US
ecu.journal.issue2
ecu.journal.nameBiochemical and Biophysical Research Communications
ecu.journal.pages203-205
ecu.journal.volume383

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