Timing of Esophagectomy after Neoadjuvant Chemoradiation Therapy Affects the Incidence of Anastomotic Leaks
dc.contributor.author | Roh, Simon | |
dc.contributor.author | Iannettoni, Mark D. | |
dc.contributor.author | Keech, John | |
dc.contributor.author | Arshava, Evgeny V. | |
dc.contributor.author | Swatek, Anthony | |
dc.contributor.author | Zimmerman, Miriam B. | |
dc.contributor.author | Weigel, Ronald J. | |
dc.contributor.author | Parekh, Kalpaj R. | |
dc.date.accessioned | 2020-04-23T18:32:11Z | |
dc.date.available | 2020-04-23T18:32:11Z | |
dc.date.issued | 2019-02-05 | |
dc.description.abstract | Background: Neoadjuvant chemoradiation therapy (nCRT) has become the standard of care for esophageal cancer patients prior to esophagectomy. However, the optimal timing for surgery after completion of nCRT remains unclear. Methods: A retrospective review was performed of patients who underwent esophagectomy with cervical anastomosis for esophageal cancer at a single institution between January 2000 and June 2015. Patients were categorized into 3 cohorts: those who did not receive nCRT prior to esophagectomy (no nCRT), those who underwent esophagectomy within 35 days after nCRT (≤35d), and those who underwent esophagectomy more than 35 days after nCRT (>35d). Results: A total of 366 esophagectomies were performed during the study period, and 348 patients met the inclusion criteria. Anastomotic leaks occurred in 11.8% of all patients included in the study (41 of 348). Within each cohort, anastomotic leaks were detected in 14.7% of patients (17 of 116) in the no nCRT cohort, 7.3% (13 of 177) in the ≤35d cohort, and 20.0% (11 of 55) in the >35d cohort (p=0.020). Significant differences in the occurrence of anastomotic leaks were observed between the no nCRT and ≤35d cohorts (p=0.044), and between the ≤35d and >35d cohorts (p=0.007). Conclusion: Esophagectomy with cervical anastomosis within 35 days of nCRT resulted in a lower percentage of anastomotic leaks. | en_US |
dc.identifier.doi | 10.5090/kjtcs.2019.52.1.1 | |
dc.identifier.uri | http://hdl.handle.net/10342/8340 | |
dc.subject | Esophageal neoplasms, Esophagectomy, Anastomotic leak, Chemoradiotherapy, Neoadjuvant therapy | en_US |
dc.title | Timing of Esophagectomy after Neoadjuvant Chemoradiation Therapy Affects the Incidence of Anastomotic Leaks | en_US |
dc.type | Article | en_US |
ecu.journal.issue | 1 | en_US |
ecu.journal.name | Korean J Thorac Cardiovasc Surg | en_US |
ecu.journal.pages | 1-8 | en_US |
ecu.journal.volume | 52 | en_US |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- kjtcv-52-001.pdf
- Size:
- 281.35 KB
- Format:
- Adobe Portable Document Format
- Description: