Prolactin and Dehydroepiandrosterone Levels in Women with Systemic Lupus Erythematosus: The Role of the Extrapituitary Prolactin Promoter Polymorphism at −1149G/T

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dc.contributor.authorTreadwell, Edward L.
dc.contributor.authorWiley, Kenneth
dc.contributor.authorWord, Beverly
dc.contributor.authorMelchior, William
dc.contributor.authorTolleson, William H.
dc.contributor.authorGopee, Neera
dc.contributor.authorHammons, George
dc.contributor.authorLyn-Cook, Beverly D.
dc.date.accessioned2016-06-10T17:59:30Z
dc.date.available2016-06-10T17:59:30Z
dc.date.issued2015
dc.description.abstractstemic lupus erythematosus (SLE) has shown an association with high levels of prolactin, low levels of dehydroepiandrosterone (DHEA), and induction of inflammatory cytokines in the serum of patients with the disease. This preliminary study examined the relevance of a −1149G/T functional single-nucleotide polymorphism (SNP) (rs1341239) in the promoter of the extrapituitary prolactin gene in a cohort of African American and European American women with lupus. Examination of this SNP revealed that the −1149TT genotype was correlated with higher levels of prolactin in serum and prolactin gene expression () in peripheral blood mononuclear cells (PBMCs). Lower levels of DHEA in serum were demonstrated in lupus patients (); those with the −1149TT genotype had the lowest levels of DHEA. Furthermore, a small subset of women who were on DHEA therapy and had a TT genotype showed a significant decrease in prolactin gene expression and lower disease activity scores (SLEDAI). Lupus patients, particularly African Americans, had significantly higher levels of IL-6 () and TNF-α (). This study suggests that the −1149TT genotype may be a risk factor for lupus and may predict who could possibly benefit from DHEA therapy; therefore, these results should be validated in a larger cohort with all ethnic groups.en_US
dc.identifier.citationJournal of Immunology Research; 2015: p. 1-10en_US
dc.identifier.doi10.1155/2015/435658
dc.identifier.issn2314-8861
dc.identifier.pmidpmc4637102en_US
dc.identifier.urihttp://hdl.handle.net/10342/5538
dc.relation.urihttp://www.hindawi.com/journals/jir/2015/435658/en_US
dc.titleProlactin and Dehydroepiandrosterone Levels in Women with Systemic Lupus Erythematosus: The Role of the Extrapituitary Prolactin Promoter Polymorphism at −1149G/Ten_US
dc.typeArticleen_US
ecu.journal.nameJournal of Immunology Researchen_US
ecu.journal.pages1-10en_US
ecu.journal.volume2015en_US

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