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Upregulation of Human T-Cell Leukemia Virus Type 1 Antisense Transcription by the Viral Tax Protein

dc.contributor.authorLandry, Sebastienen_US
dc.contributor.authorHalin, Marileneen_US
dc.contributor.authorVargas, Amandineen_US
dc.contributor.authorLemasson, Isabelleen_US
dc.contributor.authorMesnard, Jean-Michelen_US
dc.contributor.authorBarbeau, Benoiten_US
dc.date.accessioned2011-04-15T15:51:48Zen_US
dc.date.accessioned2011-05-17T01:40:10Z
dc.date.available2011-04-15T15:51:48Zen_US
dc.date.available2011-05-17T01:40:10Z
dc.date.issued2009-02en_US
dc.description.abstractSeveral studies have recently demonstrated the existence of human T-cell leukemia virus type 1 (HTLV-1) antisense transcripts, which allow the synthesis of the newly described HBZ protein. Although previous reports have been aimed at understanding the potential role of the HBZ protein in HTLV-1 pathogenesis, little is known as to how this viral gene is regulated. Here, using our K30-3 asLuc reporter construct, we show that the viral Tax protein upregulates antisense transcription through its action on the TRE sequences located in the 3 long terminal repeat. Generation of stable clones in 293T cells demonstrated that Tax-induced HBZ expression is importantly influenced by the integration site in the host genome. The cellular DNA context could thus affect the level of HBZ mRNA expression in infected cells. Originally published Journal of Virology, Vol. 83, No. 4, Feb 2009en_US
dc.identifier.citationJournal of Virology; 83:4 p. 2048-2054en_US
dc.identifier.pmidPMC2643783en_US
dc.identifier.urihttp://hdl.handle.net/10342/3334en_US
dc.language.isoen_USen_US
dc.publisherEast Carolina Universityen_US
dc.relation.urihttp://jvi.asm.org/cgi/content/abstract/83/4/2048en_US
dc.rightsAuthor notified of opt-out rights by Cammie Jennings prior to upload of this article.en_US
dc.subjectHTLV-1en_US
dc.subjectHBZ proteinen_US
dc.subjectAntisense transcriptsen_US
dc.titleUpregulation of Human T-Cell Leukemia Virus Type 1 Antisense Transcription by the Viral Tax Proteinen_US
dc.typeArticleen_US

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