Measles vaccine vectors and methods of use
| dc.contributor.author | Ross, Ted | |
| dc.contributor.author | Robinson, Harriet | |
| dc.date.accessioned | 2019-11-11T18:38:40Z | |
| dc.date.available | 2019-11-11T18:38:40Z | |
| dc.date.issued | 2003-03-20 | |
| dc.description.abstract | The present invention provides a novel vaccine expressing a fusion of the measles hemagglutinin (H) protein and the complement component, C3d, to enhance the titers of neutralizing antibody. Plasmids were generated that expressed a secreted (s) form of H and the same form fused to three tandem copies of the murine homologue of C3d (sH-3C3d). Analysis of titers of the antibody raised in vaccinated mice indicated that groups vaccinated with the DNA construct expressing sH-3C3d had higher titers of anti-H antibodies compared to serum from mice vaccinated with DNA expressing sH only. In addition, sH-3C3d elicited higher neutralizing antibody titers that inhibited MV induced plaque formation. | en_US |
| dc.identifier.other | International Publication #WO2003022204A2 | |
| dc.identifier.other | US Pat# US28262101P | |
| dc.identifier.uri | http://hdl.handle.net/10342/7541 | |
| dc.language.iso | en_US | en_US |
| dc.relation.uri | https://patents.google.com/patent/WO2003022204A2/en?oq=inassignee:%22East+Carolina%22 | en_US |
| dc.subject | immunization | en_US |
| dc.subject | Vaccine | en_US |
| dc.title | Measles vaccine vectors and methods of use | en_US |
| dc.type | Patent | en_US |
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