Neuroantigen-specific, tolerogenic vaccines: GM-CSF is a fusion partner that facilitates tolerance rather than immunity to dominant self-epitopes of myelin in murine models of experimental autoimmune encephalomyelitis (EAE)
dc.contributor.author | Abbott, Derek J. | |
dc.contributor.author | Blanchfield, J. Lori | |
dc.contributor.author | Martinson, David A | |
dc.contributor.author | Russell, Sean C | |
dc.contributor.author | Taslim, Najla | |
dc.contributor.author | Curtis II, Alan Dale | |
dc.contributor.author | Mannie, Mark D | |
dc.date.accessioned | 2020-04-02T17:45:54Z | |
dc.date.available | 2020-04-02T17:45:54Z | |
dc.date.issued | 2011-12-30 | |
dc.description.abstract | BACKGROUND: Vaccination strategies that elicit antigen-specific tolerance are needed as therapies for autoimmune disease. This study focused on whether cytokine-neuroantigen (NAg) fusion proteins could inhibit disease in chronic murine models of experimental autoimmune encephalomyelitis (EAE) and thus serve as potential therapeutic modalities for multiple sclerosis. RESULTS: A fusion protein comprised of murine GM-CSF as the N-terminal domain and the encephalitogenic MOG35-55 peptide as the C-terminal domain was tested as a tolerogenic, therapeutic vaccine (TTV) in the C57BL/6 model of EAE. Administration of GMCSF-MOG before active induction of EAE, or alternatively, at the onset of EAE blocked the development and progression of EAE. Covalent linkage of the GM-CSF and MOG35-55 domains was required for tolerogenic activity. Likewise, a TTV comprised of GM-CSF and PLP139-151 was a tolerogen in the SJL model of EAE. CONCLUSION: These data indicated that fusion proteins containing GM-CSF coupled to myelin auto-antigens elicit tolerance rather than immunity. | en_US |
dc.identifier.doi | 10.1186/1471-2172-12-72 | |
dc.identifier.uri | http://hdl.handle.net/10342/7744 | |
dc.title | Neuroantigen-specific, tolerogenic vaccines: GM-CSF is a fusion partner that facilitates tolerance rather than immunity to dominant self-epitopes of myelin in murine models of experimental autoimmune encephalomyelitis (EAE) | en_US |
dc.type | Article | en_US |
ecu.journal.issue | 72 | en_US |
ecu.journal.name | BMC Immunology | en_US |
ecu.journal.pages | 1-18 | en_US |
ecu.journal.volume | 12 | en_US |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- 1471-2172-12-72.pdf
- Size:
- 2.23 MB
- Format:
- Adobe Portable Document Format
- Description: