Evaluation of Methicillin-Resistant Staphylococcus aureus Carriage and High Livestock Production Areas in North Carolina through Active Case Finding at a Tertiary Care Hospital
dc.contributor.author | Feingold, Beth J. | |
dc.contributor.author | Augustino, Kerri L. | |
dc.contributor.author | Curriero, Frank C. | |
dc.contributor.author | Udani, Paras C. | |
dc.contributor.author | Ramsey, Keith M. | |
dc.date.accessioned | 2020-04-13T17:09:58Z | |
dc.date.available | 2020-04-13T17:09:58Z | |
dc.date.issued | 2019-09-14 | |
dc.description.abstract | : Recent reports from the Netherlands document the emergence of novel multilocus sequence typing (MLST) types (e.g., ST-398) of methicillin-resistant Staphylococcus aureus (MRSA) in livestock, particularly swine. In Eastern North Carolina (NC), one of the densest pig farming areas in the United States, as many as 14% of MRSA isolates from active case finding in our medical center have no matches in a repetitive sequence-based polymerase chain reaction (rep-PCR) library. The current study was designed to determine if these non-matched MRSA (NM-MRSA) were geographically associated with exposure to pig farming in Eastern NC. While residential proximity to farm waste lagoons lacked association with NM-MRSA in a logistic regression model, a spatial cluster was identified in the county with highest pig density. Using MLST, we found a heterogeneous distribution of strain types comprising the NM-MRSA isolates from the most pig dense regions, including ST-5 and ST-398. Our study raises the warning that patients in Eastern NC harbor livestock associated MRSA strains are not easily identifiable by rep-PCR. Future MRSA studies in livestock dense areas in the U.S. should investigate further the role of pig–human interactions. | en_US |
dc.identifier.doi | 10.3390/ijerph16183418 | |
dc.identifier.uri | http://hdl.handle.net/10342/8092 | |
dc.subject | MRSA; MLST; rep-PCR; North Carolina; livestock; cluster detection | en_US |
dc.title | Evaluation of Methicillin-Resistant Staphylococcus aureus Carriage and High Livestock Production Areas in North Carolina through Active Case Finding at a Tertiary Care Hospital | en_US |
dc.type | Article | en_US |
ecu.journal.name | International Journal of Environmental Research and Public Health | en_US |
ecu.journal.pages | 3418 | en_US |
ecu.journal.volume | 16 | en_US |
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