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Presenilin-1 inhibits delta-catenin-induced cellular branching and promotes delta-catenin processing and turnover

dc.contributor.authorKim, Jin-Sooken_US
dc.contributor.authorBareiss, Sonjaen_US
dc.contributor.authorKim, Kyung Keunen_US
dc.contributor.authorTatum, Rodneyen_US
dc.contributor.authorHan, Jeong-Ranen_US
dc.contributor.authorJin, Yun Hyeen_US
dc.contributor.authorKim, Hangunen_US
dc.contributor.authorLu, Qunen_US
dc.contributor.authorKim, Kwonseopen_US
dc.date.accessioned2011-04-15T15:13:05Zen_US
dc.date.accessioned2011-05-17T13:03:52Z
dc.date.available2011-04-15T15:13:05Zen_US
dc.date.available2011-05-17T13:03:52Z
dc.date.issued2006-12-29en_US
dc.description.abstractAlthough delta-catenin/neural plakophilin-related armadillo protein (NPRAP) was reported to interact with presenilin-1 (PS-1), the effects of PS-1 on delta-catenin have not been established. In this study, we report that overexpression of PS-1 inhibits the delta-catenin-induced dendrite-like morphological changes in NIH 3T3 cells and promotes delta-catenin processing and turnover. The effects of PS-1 on endogenous delta-catenin processing were confirmed in hippocampal neurons overexpressing PS-1, as well as in the transgenic mice expressing the disease-causing mutant PS-1 (M146V). In addition, disease-causing mutant PS-1 (M146V and L286V) enhanced delta-catenin processing, whereas PS-1/gamma-secretase inhibitors could block the formation of processed forms of delta-catenin. Together, our findings suggest that PS-1 can affect delta-catenin-induced morphogenesis possibly through the regulation of its processing and stability. Originally published Biochem Biophys Res Commun, Vol. 351, No. 4, Dec 2006en_US
dc.identifier.citationBiochemical and Biophysical Research Communications; 351:4 p. 903-908en_US
dc.identifier.pmidPMC1800877en_US
dc.identifier.urihttp://hdl.handle.net/10342/3325en_US
dc.language.isoen_USen_US
dc.publisherEast Carolina Universityen_US
dc.relation.urihttp://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WBK-4M813W6-9&_user=634873&_coverDate=12%2F29%2F2006&_rdoc=1&_fmt=high&_orig=gateway&_origin=gateway&_sort=d&_docanchor=&view=c&_acct=C000033758&_version=1&_urlVersion=0&_userid=634873&md5=714fba29e7d7e581fa9873bc56ac1f2b&searchtype=aen_US
dc.rightsAuthor notified of opt-out rights by Cammie Jennings prior to upload of this article.en_US
dc.subjectAlzheimer's diseaseen_US
dc.subject[Delta]-catenin/NPRAPen_US
dc.subjectPresenilin/gamma-secretaseen_US
dc.subjectδ-catenin/NPRAP
dc.titlePresenilin-1 inhibits delta-catenin-induced cellular branching and promotes delta-catenin processing and turnoveren_US
dc.typeArticleen_US

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