Challenges and Solutions in the Development of Genomic Biomarker Panels: A Systematic Phased Approach

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dc.contributor.authorShahzad, K
dc.contributor.authorFatima, A
dc.contributor.authorCadeiras, Martin
dc.contributor.authorWisniewski, N
dc.contributor.authorBondar, Galyna
dc.contributor.authorCheng, R
dc.contributor.authorReed, E
dc.contributor.authorDeng, Mario C.
dc.date.accessioned2016-06-10T18:25:21Z
dc.date.available2016-06-10T18:25:21Z
dc.date.issued2012-06
dc.description.abstractIn the post-genome era, high throughput gene expression profiling has been successfully used to develop genomic biomarker panels (GBP) that can be integrated into clinical decision making. The development of GBPs in the context of personalized medicine is a scientifically challenging and resource-intense process. It needs to be accomplished in a systematic phased approach to address biological variation related to a clinical phenotype (e.g. disease etiology, gender, etc.) and minimize technical variation (noise). Here we present the methodological aspects of GBP development based on the experience of the Cardiac Allograft Rejection Gene Expression Observation (CARGO) study, a study that lead to the development of a molecular classifier for rejection screening in heart transplant patients.en_US
dc.identifier.citationCurrent Genomics; 13:4 p. 334-341en_US
dc.identifier.doi10.2174/138920212800793339
dc.identifier.issn1389-2029
dc.identifier.pmidpmc3394121en_US
dc.identifier.urihttp://hdl.handle.net/10342/5544
dc.relation.urihttp://www.ncbi.nlm.nih.gov/pubmed/23204923en_US
dc.subjectPost-genome eraen_US
dc.subjectbiomarker panelsen_US
dc.subjectgene expression profilingen_US
dc.subjectgenomicsen_US
dc.subjectheart transplantationen_US
dc.subjectmolecular classifieren_US
dc.subjectmultiorgan dysfunctionen_US
dc.subjectpersonalized medicineen_US
dc.titleChallenges and Solutions in the Development of Genomic Biomarker Panels: A Systematic Phased Approachen_US
dc.typeArticleen_US
ecu.journal.issue4en_US
ecu.journal.nameCurrent Genomicsen_US
ecu.journal.pages334-341en_US
ecu.journal.volume13en_US

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