Acute Adverse Effects of Fine Particulate Air Pollution on Ventricular Repolarization

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dc.contributor.authorLiao, Duanping
dc.contributor.authorShaffer, Michele L.
dc.contributor.authorRodriguez-Colon, Sol
dc.contributor.authorHe, Fan
dc.contributor.authorLi, Xian
dc.contributor.authorWolbrette, Deborah L.
dc.contributor.authorYanosky, Jeff D.
dc.contributor.authorCascio, Wayne E.
dc.date.accessioned2016-06-01T12:20:17Z
dc.date.available2016-06-01T12:20:17Z
dc.date.issued2010-07
dc.description.abstractBackground The mechanisms for the relationship between particulate pollution and cardiac disease are not fully understood. Objective We examined the effects and time course of exposure to fine particulate matter ≤ 2.5 μm in aerodynamic diameter (PM2.5) on ventricular repolarization of 106 nonsmoking adults who were living in communities in central Pennsylvania. Methods The 24-hr beat-to-beat electrocardiogram (ECG) data were obtained using a high-resolution 12-lead Holter system. After visually identifying and removing artifacts and arrhythmic beats, we summarized normal beat-to-beat QTs from each 30-min segment as heart rate (HR)-corrected QT measures: QT prolongation index (QTI), Bazett’s HR-corrected QT (QTcB), and Fridericia’s HR-corrected QT (QTcF). A personal PM2.5 monitor was used to measure individual-level real-time PM2.5 exposures for 24 hr. We averaged these data and used 30-min time-specific average PM2.5 exposures. Results The mean age of the participants was 56 ± 8 years, with 41% male and 74% white. The means ± SDs for QTI, QTcB, and QTcF were 111 ± 6.6, 438 ± 23 msec, and 422 ± 22 msec, respectively; and for PM2.5, the mean ± SD was 14 ± 22 μg/m3. We used distributed lag models under a framework of linear mixed-effects models to assess the autocorrelation-corrected regression coefficients (β) between 30-min PM2.5 and the HR-corrected QT measures. Most of the adverse ventricular repolarization effects from PM2.5 exposure occurred within 3–4 hr. The multivariable adjusted β (SE, p-value) due to a 10-μg/m3 increase in lag 7 PM2.5 on QTI, QTcB, and QTcF were 0.08 (0.04, p < 0.05), 0.22 (0.08, p < 0.01), and 0.09 (0.05, p < 0.05), respectively. Conclusions Our results suggest a significant adverse effect of PM2.5 on ventricular repolarization. The time course of the effect is within 3–4 hr of elevated PM2.5.en_US
dc.identifier.citationEnvironmental Health Perspectives; 118:7 p. 1010-1015en_US
dc.identifier.doi10.1289/ehp.0901648
dc.identifier.issn0091-6765
dc.identifier.pmidpmc2920900en_US
dc.identifier.urihttp://hdl.handle.net/10342/5434
dc.relation.urihttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920900/en_US
dc.subjectautonomic modulationen_US
dc.subjectcardiovascular diseaseen_US
dc.subjectparticulate matteren_US
dc.subjectQT intervalen_US
dc.subjectventricular repolarizationen_US
dc.titleAcute Adverse Effects of Fine Particulate Air Pollution on Ventricular Repolarizationen_US
dc.typeArticleen_US
ecu.journal.issue7en_US
ecu.journal.nameEnvironmental Health Perspectivesen_US
ecu.journal.pages1010-1015en_US
ecu.journal.volume118en_US

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