Molecular Connections between Cancer Cell Metabolism and the Tumor Microenvironment

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dc.contributor.authorCalvin, Justin R.
dc.contributor.authorSanderlin, Edward J.
dc.contributor.authorYang, Li V.
dc.date.accessioned2020-04-17T16:06:34Z
dc.date.available2020-04-17T16:06:34Z
dc.date.issued2015
dc.description.abstractCancer cells preferentially utilize glycolysis, instead of oxidative phosphorylation, for metabolism even in the presence of oxygen. This phenomenon of aerobic glycolysis, referred to as the “Warburg effect”, commonly exists in a variety of tumors. Recent studies further demonstrate that both genetic factors such as oncogenes and tumor suppressors and microenvironmental factors such as spatial hypoxia and acidosis can regulate the glycolytic metabolism of cancer cells. Reciprocally, altered cancer cell metabolism can modulate the tumor microenvironment which plays important roles in cancer cell somatic evolution, metastasis, and therapeutic response. In this article, we review the progression of current understandings on the molecular interaction between cancer cell metabolism and the tumor microenvironment. In addition, we discuss the implications of these interactions in cancer therapy and chemopreventioen_US
dc.identifier.doi10.3390/ijms160511055
dc.identifier.urihttp://hdl.handle.net/10342/8149
dc.subjecttumor microenvironment; cancer cell metabolism; hypoxia; acidosis; cancer therapyen_US
dc.titleMolecular Connections between Cancer Cell Metabolism and the Tumor Microenvironmenten_US
dc.typeArticleen_US
ecu.journal.issue5en_US
ecu.journal.nameInternational Journal of Molecular Sciencesen_US
ecu.journal.pages11055-11086en_US
ecu.journal.volume16en_US

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