Acute Effects of Fine Particulate Air Pollution on Cardiac Arrhythmia: The APACR Study

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dc.contributor.authorHe, Fan
dc.contributor.authorShaffer, Michele L.
dc.contributor.authorRodriguez-Colon, Sol
dc.contributor.authorYanosky, Jeff D.
dc.contributor.authorBixler, Edward O.
dc.contributor.authorCascio, Wayne E.
dc.contributor.authorLiao, Duanping
dc.date.accessioned2016-05-31T17:19:41Z
dc.date.available2016-05-31T17:19:41Z
dc.date.issued2011-03
dc.description.abstractBackground: The mechanisms underlying the relationship between particulate matter (PM) air pollution and cardiac disease are not fully understood. Objectives: We examined the effects and time course of exposure to fine PM [aerodynamic diameter ≤ 2.5 μm (PM2.5)] on cardiac arrhythmia in 105 middle-age community-dwelling healthy nonsmokers in central Pennsylvania. Methods: The 24-hr beat-to-beat electrocardiography data were obtained using a high-resolution Holter system. After visually identifying and removing artifacts, we summarized the total number of premature ventricular contractions (PVCs) and premature atrial contractions (PACs) for each 30-min segment. A personal PM2.5 nephelometer was used to measure individual-level real-time PM2.5 exposures for 24 hr. We averaged these data to obtain 30-min average time–specific PM2.5 exposures. Distributed lag models under the framework of negative binomial regression and generalized estimating equations were used to estimate the rate ratio between 10-μg/m3 increases in average PM2.5 over 30-min intervals and ectopy counts. Results: The mean ± SD age of participants was 56 ± 8 years, with 40% male and 73% non-Hispanic white. The 30-min mean ± SD for PM2.5 exposure was 13 ± 22 μg/m3, and PAC and PVC counts were 0.92 ± 4.94 and 1.22 ± 7.18. Increases of 10 μg/m3 in average PM2.5 concentrations during the same 30 min or the previous 30 min were associated with 8% and 3% increases in average PVC counts, respectively. PM2.5 was not significantly associated with PAC count. Conclusion: PM2.5 exposure within approximately 60 min was associated with increased PVC counts in healthy individuals.en_US
dc.identifier.citationEnvironmental Health Perspectives; 119:7 p. 927-932en_US
dc.identifier.doi10.1289/ehp.1002640
dc.identifier.issn0091-6765
dc.identifier.pmidpmc3222979en_US
dc.identifier.urihttp://hdl.handle.net/10342/5430
dc.relation.urihttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222979/en_US
dc.subjectcardiac arrhythmiaen_US
dc.subjectcardiovascular diseaseen_US
dc.subjectPACen_US
dc.subjectparticulate matteren_US
dc.subjectPVCen_US
dc.titleAcute Effects of Fine Particulate Air Pollution on Cardiac Arrhythmia: The APACR Studyen_US
dc.typeArticleen_US
ecu.journal.issue7en_US
ecu.journal.nameEnvironmental Health Perspectivesen_US
ecu.journal.pages927-932en_US
ecu.journal.volume119en_US

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