The Short-Term Effect of Weight Loss Surgery on Volumetric Breast Density and Fibroglandular Volume

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dc.contributor.authorVohra, Nasreen A.
dc.contributor.authorKachare, Swapnil D.
dc.contributor.authorVos, Paul
dc.contributor.authorSchroeder, Bruce F.
dc.contributor.authorSchuth, Olga
dc.contributor.authorSuttle, Dylan
dc.contributor.authorFitzgerald, Timothy L.
dc.contributor.authorWong, Jan H.
dc.contributor.authorVerbanac, Kathryn M.
dc.date.accessioned2016-11-04T13:48:52Z
dc.date.available2016-11-04T13:48:52Z
dc.date.issued2016-10-26
dc.description.abstractPurpose: Obesity and breast density are both associated with an increased risk of breast cancer and are potentially modifiable. Weight loss surgery (WLS) causes a significant reduction in the amount of body fat and a decrease in breast cancer risk. The effect of WLS on breast density and its components has not been documented. Here, we analyze the impact of WLS on volumetric breast density (VBD) and on each of its components (fibroglandular volume and breast volume) by using three-dimensional methods. Materials and Methods: Fibroglandular volume, breast volume, and their ratio, the VBD, were calculated from mammograms before and after WLS by using Volpara™ automated software. Results: For the 80 women included, average body mass index decreased from 46.0 ± 7.22 to 33.7 ± 7.06 kg/m2. Mammograms were performed on average 11.6 ± 9.4 months before and 10.1 ± 7 months after WLS. There was a significant reduction in average breast volume (39.4 % decrease) and average fibroglandular volume (15.5 % decrease), and thus, the average VBD increased from 5.15 to 7.87 % (p < 1 × 10−9) after WLS. When stratified by menopausal status and diabetic status, VBD increased significantly in all groups but only perimenopausal and postmenopausal women and non-diabetics experienced a significant reduction in fibroglandular volume. Conclusions: Breast volume and fibroglandular volume decreased, and VBD increased following WLS, with the most significant change observed in postmenopausal women and non-diabetics. Further studies are warranted to determine how physical and biological alterations in breast density components after WLS may impact breast cancer risk.en_US
dc.description.sponsorshipECU Open Access Publishing Support Funden_US
dc.identifier.citationVohra, N.A., Kachare, S.D., Vos, P. et al. OBES SURG (2016). doi:10.1007/s11695-016-2415-6en_US
dc.identifier.doi10.1007/s11695-016-2415-6
dc.identifier.pmid27783370en_US
dc.identifier.urihttp://hdl.handle.net/10342/5976
dc.language.isoenen_US
dc.relation.urihttp://link.springer.com/article/10.1007/s11695-016-2415-6en_US
dc.subjectWeight loss surgeryen_US
dc.subjectFibroglandular volumeen_US
dc.subjectVolumetric breast densityen_US
dc.subjectBreast densityen_US
dc.subjectBreast canceren_US
dc.subjectObesityen_US
dc.subjectDiabetesen_US
dc.subjectBreast volumeen_US
dc.titleThe Short-Term Effect of Weight Loss Surgery on Volumetric Breast Density and Fibroglandular Volumeen_US
dc.typeArticleen_US
ecu.journal.nameObesity Surgeryen_US
ecu.journal.pages1-11en_US

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