Effect of testosterone replacement or duration of castration on baroreflex bradycardia in conscious rats
dc.contributor.author | Ward, Gregg R. | en_US |
dc.contributor.author | Abdel-Rahman, Abdel A. | en_US |
dc.date.accessioned | 2011-04-28T19:28:35Z | en_US |
dc.date.accessioned | 2011-05-17T13:10:57Z | |
dc.date.available | 2011-04-28T19:28:35Z | en_US |
dc.date.available | 2011-05-17T13:10:57Z | |
dc.date.issued | 2005-03-30 | en_US |
dc.description.abstract | Background: In this study, we tested the hypothesis that 17β-estradiol contributes to testosterone-mediated restoration of baroreflex-mediated bradycardia in short-term (3 weeks) castrated rats. Further, a reported increase in serum testosterone after long-term (6 weeks) castration constituted a basis for testing the hypothesis that a spontaneous increase in serum testosterone or androstenedione in this model causes a commensurate increase in baroreflexmediated bradycardia. Results: Testosterone (1 week) replacement enhanced baroreflex-mediated bradycardia in shortterm castrated rats without changing 17β-estradiol level. A spontaneous recovery of baroreflexmediated bradycardia occurred following long-term castration, although circulating testosterone and androstenedione remained suppressed. Conclusion: The data suggest: 1) 17β-Estradiol does not contribute to testosterone restoration of the baroreflex-mediated bradycardia in short-term castrated rats. 2) The long-term modulation of baroreflex-mediated bradycardia occurs independent of androgens, or the baroreflex mechanism may become adapted to low levels of circulating androgens. Originally published BMC Pharmacology, Vol. 5, No. 9, Mar 2005 | en_US |
dc.identifier.citation | BMC Pharmacology; 5:9 p. 1-6 | en_US |
dc.identifier.doi | 10.1186/1471-2210-5-9 | |
dc.identifier.pmid | PMC1079884 | en_US |
dc.identifier.uri | http://hdl.handle.net/10342/3435 | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | East Carolina University | en_US |
dc.relation.uri | http://www.biomedcentral.com/1471-2210/5/9 | en_US |
dc.rights | Author notified of opt-out rights by Cammie Jennings prior to upload of this article. | en_US |
dc.subject | Baroreflex bradycardia | en_US |
dc.subject | Testosterone replacement | en_US |
dc.subject | Castration duration | en_US |
dc.title | Effect of testosterone replacement or duration of castration on baroreflex bradycardia in conscious rats | en_US |
dc.type | Article | en_US |
ecu.journal.issue | 9 | |
ecu.journal.name | BMC Pharmacology | |
ecu.journal.pages | 1-6 | |
ecu.journal.volume | 5 |
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