Effect of testosterone replacement or duration of castration on baroreflex bradycardia in conscious rats

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dc.contributor.authorWard, Gregg R.en_US
dc.contributor.authorAbdel-Rahman, Abdel A.en_US
dc.date.accessioned2011-04-28T19:28:35Zen_US
dc.date.accessioned2011-05-17T13:10:57Z
dc.date.available2011-04-28T19:28:35Zen_US
dc.date.available2011-05-17T13:10:57Z
dc.date.issued2005-03-30en_US
dc.description.abstractBackground: In this study, we tested the hypothesis that 17β-estradiol contributes to testosterone-mediated restoration of baroreflex-mediated bradycardia in short-term (3 weeks) castrated rats. Further, a reported increase in serum testosterone after long-term (6 weeks) castration constituted a basis for testing the hypothesis that a spontaneous increase in serum testosterone or androstenedione in this model causes a commensurate increase in baroreflexmediated bradycardia. Results: Testosterone (1 week) replacement enhanced baroreflex-mediated bradycardia in shortterm castrated rats without changing 17β-estradiol level. A spontaneous recovery of baroreflexmediated bradycardia occurred following long-term castration, although circulating testosterone and androstenedione remained suppressed. Conclusion: The data suggest: 1) 17β-Estradiol does not contribute to testosterone restoration of the baroreflex-mediated bradycardia in short-term castrated rats. 2) The long-term modulation of baroreflex-mediated bradycardia occurs independent of androgens, or the baroreflex mechanism may become adapted to low levels of circulating androgens. Originally published BMC Pharmacology, Vol. 5, No. 9, Mar 2005en_US
dc.identifier.citationBMC Pharmacology; 5:9 p. 1-6en_US
dc.identifier.doi10.1186/1471-2210-5-9
dc.identifier.pmidPMC1079884en_US
dc.identifier.urihttp://hdl.handle.net/10342/3435en_US
dc.language.isoen_USen_US
dc.publisherEast Carolina Universityen_US
dc.relation.urihttp://www.biomedcentral.com/1471-2210/5/9en_US
dc.rightsAuthor notified of opt-out rights by Cammie Jennings prior to upload of this article.en_US
dc.subjectBaroreflex bradycardiaen_US
dc.subjectTestosterone replacementen_US
dc.subjectCastration durationen_US
dc.titleEffect of testosterone replacement or duration of castration on baroreflex bradycardia in conscious ratsen_US
dc.typeArticleen_US
ecu.journal.issue9
ecu.journal.nameBMC Pharmacology
ecu.journal.pages1-6
ecu.journal.volume5

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