Repository logo
 

Feminizing Adrenal Carcinoma Presenting with Heart Failure and Ventricular Tachycardia

dc.contributor.authorHarnoor, Anjana
dc.contributor.authorWest, R. Lee
dc.contributor.authorCook, Fiona J.
dc.date.accessioned2016-06-10T18:04:50Z
dc.date.available2016-06-10T18:04:50Z
dc.date.issued2012
dc.description.abstractWe present a case of feminizing adrenal carcinoma with severe elevation in serum estradiol and otherwise unexplained congestive heart failure with ventricular arrhythmia and review the literature on feminizing adrenal tumors and the potential relationship between estrogen and cardiac problems. A 54-year-old man presented with congestive heart failure and ventricular arrhythmia. Imaging revealed a large adrenal mass. Hormonal evaluation revealed a very high serum level of estradiol, elevated DHEA-sulfate and androstenedione, and lack of cortisol suppression on a low-dose overnight dexamethasone suppression test. The patient underwent a left adrenalectomy with subsequent normalization of serum estradiol. Surgical pathology examination established adrenocortical carcinoma MacFarlane stage II. Upon 15-month followup, the patient continued to have a normal serum estradiol level, his cardiac function was significantly improved, and he had no further episodes of ventricular arrhythmia. To the best of our knowledge, the serum estradiol level that was detected in our case is the highest that has been reported. Further, we hypothesize that the very high serum concentration of estradiol in our case may have played a role in his cardiac presentation with congestive heart failure and arrhythmia, particularly as these problems resolved with normalization of his serum estradiol level.en_US
dc.identifier.citationCase Reports in Endocrinology; 2012: p. 1-5en_US
dc.identifier.doi10.1155/2012/760134
dc.identifier.issn2090-6501
dc.identifier.pmidpmc3420512en_US
dc.identifier.urihttp://hdl.handle.net/10342/5542
dc.relation.urihttp://www.hindawi.com/journals/crie/2012/760134/en_US
dc.titleFeminizing Adrenal Carcinoma Presenting with Heart Failure and Ventricular Tachycardiaen_US
dc.typeArticleen_US
ecu.journal.nameCase Reports in Endocrinologyen_US
ecu.journal.pages1-5en_US
ecu.journal.volume2012en_US

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
CRIM.ENDOCRINOLOGY2012-760134.PMC3420512.pdf
Size:
1.9 MB
Format:
Adobe Portable Document Format