Brain stem adenosine receptors modulate centrally mediated hypotensive responses in conscious rats: A review

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dc.contributor.authorNassar, Noha N.
dc.contributor.authorAbdel-Rahman, Abdel A.
dc.date.accessioned2016-06-27T16:17:59Z
dc.date.available2016-06-27T16:17:59Z
dc.date.issued2014-12
dc.description.abstractAbbreviations: A2A, adenosine subtype A2A receptor; A1, adenosine subtype A1 receptor; ABC, avidin biotin complex; ABD rat, aortic barodenervated rat; α2 AR, alpha 2 adrenergic receptor; αMNE, alpha methyl norepinephrine; ATP, adenosine triphosphate; BP, blood pressure; cAMP, cyclic adenosine monophosphate; CGS21680, 2-[4-[(2-carboxyethyl)phenyl]ethylaminophenyl]ethylamino]-5′-N-ethylcarboxamidoadenosine. Selective A2A receptor agonist; CNS, central nervous system; CPA, N6-cyclopentyladenosine. Selective A1 receptor agonist; DAG, diacylglycerol; DPCPX, 8-cyclopentyl-1,3-dipropylxanthine. Selective A1 receptor antagonist; I1, imidazoline subtype 1 receptor; I.C., intracisternal; IP3, Inositol Triphosphate; I.V., intravenous; JNK, C-Jun N-terminal kinase; L-NAME, Nω-nitro-l-arginine methyl ester hydrochloride. Non-selective nitric oxide synthase inhibitor; NOS, nitric oxide synthase; NO, nitric oxide; NTS, nucleus tractus solitarius; PC-PLC, phosphatidyl choline-selective phospholipase C; PC12 cells, pheochromocytoma cells; PD98059, selective extracellular signal regulated kinase inhibitor; ERK1/2, extracellular signal regulated kinase; PDE, phosphodiesterase; PKA, protein kinase A; RVLM, rostral ventrolateral medulla; SAPK, stress activated protein kinase; SCH58261, 5-amino-7-(2-phenylethyl)-2-(2-furyl)-pyrazolo[4,3-∈]-1,2,4-triazolo[1,5-c]pyrimidine. Selective adenosine A2A antagonist; SHR, spontaneously hypertensive rat; SND, sympathetic neuronal discharge; SO, sham operated = conscious normotensive rats; 8-SPT, 8-(p-sulfophenyl)-theophylline. Non-selective adenosine receptor blocker; WKY, Wistar Kyoto raten_US
dc.identifier.citationJournal of Advanced Research; 6:3 p. 331-340en_US
dc.identifier.doi10.1016/j.jare.2014.12.005
dc.identifier.issn2090-1232
dc.identifier.pmidpmc4522583en_US
dc.identifier.urihttp://hdl.handle.net/10342/5757
dc.relation.urihttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522583/en_US
dc.subjectImidazoline I1-receptoren_US
dc.subjectCentrally mediated hypotensionen_US
dc.subjectClonidineen_US
dc.subjectCentral adenosine receptorsen_US
dc.subjectConscious ratsen_US
dc.subjectMAPK-NOS signalingen_US
dc.titleBrain stem adenosine receptors modulate centrally mediated hypotensive responses in conscious rats: A reviewen_US
dc.typeArticleen_US
ecu.journal.issue3en_US
ecu.journal.nameJournal of Advanced Researchen_US
ecu.journal.pages331-340en_US
ecu.journal.volume6en_US

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