Neurogenic inflammation and sensitivity to environmental chemicals.

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dc.contributor.authorMeggs, William J.en_US
dc.date.accessioned2011-01-21T19:19:15Zen_US
dc.date.accessioned2011-05-17T00:15:25Z
dc.date.available2011-01-21T19:19:15Zen_US
dc.date.available2011-05-17T00:15:25Z
dc.date.issued1993-08en_US
dc.description.abstractNeurogenic inflammation as a pathway distinct from antigen-driven, immune-mediated inflammation may play a pivotal role in understanding a broad class of environmental health problems resulting from chemical exposures. Recent progress in understanding the mediators, triggers, and regulation of neurogenic inflammation is reviewed. Evidence for and speculations about a role for neurogenic inflammation in established disorders such as asthma, rhinitis, contact dermatitis, migraine headache, and rheumatoid arthritis are presented. The sick building syndrome and multiple chemical sensitivity syndrome have been defined as clinical entities in which exposure to chemical inhalants gives rise to disease. Current data on the existence of chemical irritant receptors in the airway and skin are discussed; neurogenic inflammation arising from stimulation of chemical irritant receptors is a possible model to explain many of the aspects of chemical sensitivities. Originally published Environ Health Perspect, Vol. 101, No. 3, August 1993en_US
dc.identifier.citationEnvironmental Health Perspectives; 101:3 p. 234-238en_US
dc.identifier.pmidPMC1519776en_US
dc.identifier.urihttp://hdl.handle.net/10342/3057en_US
dc.language.isoen_USen_US
dc.publisherEast Carolina Universityen_US
dc.relation.urihttp://ehp.niehs.nih.gov/docs/montharch.html#2000en_US
dc.subjectAsthmaen_US
dc.subjectIndoor air pollutionen_US
dc.subjectMultiple chemical sensitivity syndromeen_US
dc.subjectNeurogenic inflammationen_US
dc.subjectNeutral endopeptidaseen_US
dc.subjectReactive airways dysfunction syndromeen_US
dc.subjectReactive upper airways dysfunction syndromeen_US
dc.subjectRhinitisen_US
dc.subjectSubstance pen_US
dc.subjectSick building syndromeen_US
dc.titleNeurogenic inflammation and sensitivity to environmental chemicals.en_US
dc.typeArticleen_US

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