Tolerogenic vaccines for Multiple Sclerosis
dc.contributor.author | Mannie, Mark D. | |
dc.contributor.author | Curtis II, Alan Dale | |
dc.date.accessioned | 2016-06-16T17:13:49Z | |
dc.date.available | 2016-06-16T17:13:49Z | |
dc.date.issued | 2013-05 | |
dc.description.abstract | Tolerogenic vaccines represent a new class of vaccine designed to re-establish immunological tolerance, restore immune homeostasis, and thereby reverse autoimmune disease. Tolerogenic vaccines induce long-term, antigen-specific, inhibitory memory that blocks pathogenic T cell responses via loss of effector T cells and gain of regulatory T cell function. Substantial advances have been realized in the generation of tolerogenic vaccines that inhibit experimental autoimmune encephalomyelitis in a preclinical setting, and these vaccines may be a prequel of the tolerogenic vaccines that may have therapeutic benefit in Multiple Sclerosis. The purpose here is to provide a snapshot of the current concepts and future prospects of tolerogenic vaccination for Multiple Sclerosis, along with the central challenges to clinical application. | en_US |
dc.identifier.citation | Human Vaccines & Immunotherapeutics; 9:5 p. 1032-1038 | en_US |
dc.identifier.doi | 10.4161/hv.23685 | |
dc.identifier.issn | 2164-5515 | |
dc.identifier.pmid | pmc3899137 | en_US |
dc.identifier.uri | http://hdl.handle.net/10342/5655 | |
dc.relation.uri | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899137/ | en_US |
dc.subject | autoimmune disease | en_US |
dc.subject | experimental autoimmune encephalomyelitis | en_US |
dc.subject | immune | en_US |
dc.subject | multiple sclerosis | en_US |
dc.subject | myelin | en_US |
dc.subject | neuroantigen | en_US |
dc.subject | T lymphocytes | en_US |
dc.subject | therapy | en_US |
dc.subject | tolerance | en_US |
dc.subject | vaccine | en_US |
dc.title | Tolerogenic vaccines for Multiple Sclerosis | en_US |
dc.type | Article | en_US |
ecu.journal.issue | 5 | en_US |
ecu.journal.name | Human Vaccines & Immunotherapeutics | en_US |
ecu.journal.pages | 1032-1038 | en_US |
ecu.journal.volume | 9 | en_US |
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