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Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells

dc.contributor.authorMcCubrey, James A.
dc.contributor.authorFitzgerald, Timothy L.
dc.contributor.authorYang, Li V.
dc.contributor.authorLertpiriyapong, Kvin
dc.contributor.authorSteelman, Linda S.
dc.contributor.authorAbrams, Stephen L.
dc.contributor.authorMontalto, Giuseppe
dc.contributor.authorCervello, Melchiorre
dc.contributor.authorNeri, Luca M.
dc.contributor.authorCocco, Lucio
dc.contributor.authorMartelli, Alberto M.
dc.contributor.authorLaidler, Piotr
dc.contributor.authorDulińska-Litewka, Joanna
dc.contributor.authorRakus, Dariusz
dc.contributor.authorGizak, Agnieszka
dc.contributor.authorNicoletti, Ferdinando
dc.contributor.authorFalzone, Luca
dc.contributor.authorCandido, Saverio
dc.contributor.authorLibra, Massimo
dc.date.accessioned2020-04-24T17:00:59Z
dc.date.available2020-04-24T17:00:59Z
dc.date.issued2017-02
dc.description.abstractVarious signaling pathways exert critical roles in the epithelial to mesenchymal transition (EMT) and cancer stem cells (CSCs). The Wnt/beta-catenin, PI3K/PTEN/ Akt/mTORC, Ras/Raf/MEK/ERK, hedgehog (Hh), Notch and TP53 pathways elicit essential regulatory influences on cancer initiation, EMT and progression. A common kinase involved in all these pathways is moon-lighting kinase glycogen synthase kinase-3 (GSK-3). These pathways are also regulated by micro-RNAs (miRs). TP53 and components of these pathways can regulate the expression of miRs. Targeting members of these pathways may improve cancer therapy in those malignancies that display their abnormal regulation. This review will discuss the interactions of the multi-functional GSK-3 enzyme in the Wnt/beta-catenin, PI3K/PTEN/Akt/mTORC, Ras/Raf/MEK/ERK, Hh, Notch and TP53 pathways. The regulation of these pathways by miRs and their effects on CSC generation, EMT, invasion and metastasis will be discussed.en_US
dc.identifier.urihttp://hdl.handle.net/10342/8388
dc.titleRoles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cellsen_US
dc.typeArticleen_US
ecu.journal.issue8en_US
ecu.journal.nameOncotargeten_US
ecu.journal.pages14221-14250en_US
ecu.journal.volume8en_US

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