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Long Noncoding RNA Expression Signatures of Metastatic Nasopharyngeal Carcinoma and Their Prognostic Value

dc.contributor.authorZhang, Wei
dc.contributor.authorWang, Lin
dc.contributor.authorZheng, Fang
dc.contributor.authorZou, Ruhai
dc.contributor.authorXie, Changqing
dc.contributor.authorGuo, Qiannan
dc.contributor.authorHu, Qian
dc.contributor.authorChen, Jianing
dc.contributor.authorYang, Xing
dc.contributor.authorYao, Herui
dc.contributor.authorSong, Erwei
dc.contributor.authorXiang, Yanqun
dc.date.accessioned2016-06-10T17:58:17Z
dc.date.available2016-06-10T17:58:17Z
dc.date.issued2015
dc.description.abstractLong noncoding RNAs (lncRNAs) have recently been found to play important roles in various cancer types. The elucidation of genome-wide lncRNA expression patterns in metastatic nasopharyngeal carcinoma (NPC) could reveal novel mechanisms underlying NPC carcinogenesis and progression. In this study, lncRNA expression profiling was performed on metastatic and primary NPC tumors, and the differentially expressed lncRNAs between these samples were identified. A total of 33,045 lncRNA probes were generated for our microarray based on authoritative data sources, including RefSeq, UCSC Knowngenes, Ensembl, and related literature. Using these probes, 8,088 lncRNAs were found to be significantly differentially expressed (2-fold). To identify the prognostic value of these differentially expressed lncRNAs, four lncRNAs (LOC84740, ENST00000498296, AL359062, and ENST00000438550) were selected; their expression levels were measured in an independent panel of 106 primary NPC samples via QPCR. Among these lncRNAs, ENST00000438550 expression was demonstrated to be significantly correlated with NPC disease progression. A survival analysis showed that a high expression level of ENST00000438550 was an independent indicator of disease progression in NPC patients (). In summary, this study may provide novel diagnostic and prognostic biomarkers for NPC, as well as a novel understanding of the mechanism underlying NPC metastasis and potential targets for future treatment.en_US
dc.identifier.citationBioMed Research International; 2015: p. 1-13en_US
dc.identifier.doi10.1155/2015/618924
dc.identifier.issn2314-6133
dc.identifier.pmidpmc4584063en_US
dc.identifier.urihttp://hdl.handle.net/10342/5537
dc.relation.urihttp://www.hindawi.com/journals/bmri/2015/618924/en_US
dc.titleLong Noncoding RNA Expression Signatures of Metastatic Nasopharyngeal Carcinoma and Their Prognostic Valueen_US
dc.typeArticleen_US
ecu.journal.nameBioMed Research Internationalen_US
ecu.journal.pages1-13en_US
ecu.journal.volume2015en_US

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