Antitumor Mechanism of the Essential Oils from Two Succulent Plants in Multidrug Resistance Leukemia Cell
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Date
2019-08-26
Authors
Poma, Paola
Labbozzetta, Manuela
McCubrey, James A.
Ramarosandratana, Aro Vonjy
Sajeva, Maurizio
Zito, Pietro
Notarbartolo, Monica
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Abstract
Drug resistance remains a major challenge in the treatment of cancer. The multiplicity
of the drug resistance determinants raises the question about the optimal strategies to deal with
them. Essential oils showed to inhibit the growth of different tumor cell types. Essential oils contain
several chemical classes of compounds whose heterogeneity of active moieties can help prevent the
development of drug resistance. In the present paper, we analyzed, by gas chromatography-mass
spectrometry the chemical composition of the essential oil of the leaves of Kalanchoe beharensis
obtained by hydrodistillation and compared the chemical composition of its essential oil with that
of Cyphostemma juttae. Our results demonstrated the anticancer and proapoptotic activities of both
species against acute myeloid leukemia on an in vitro model and its multidrug resistant variant
involving NF-κB pathway. The essential oils of both species produced a significant decrease in many
targets of NF-κB both at mRNA and protein levels. The results corroborate the idea that essential
oils may be a good alternative to traditional drugs in the treatment of cancer, especially in drug
resistant cancer.