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In Vivo Blood Glucose Quantification Using Raman Spectroscopy

dc.contributor.authorShao, Jingwei
dc.contributor.authorLin, Manman
dc.contributor.authorLi, Yong-Qing
dc.contributor.authorLi, Xue
dc.contributor.authorLiu, Junxian
dc.contributor.authorLiang, Jianpin
dc.contributor.authorYao, Huilu
dc.date.accessioned2016-06-27T18:42:30Z
dc.date.available2016-06-27T18:42:30Z
dc.date.issued2012
dc.description.abstractWe here propose a novel Raman spectroscopy method that permits the noninvasive measurement of blood glucose concentration. To reduce the effects of the strong background signals produced by surrounding tissue and to obtain the fingerprint Raman lines formed by blood analytes, a laser was focused on the blood in vessels in the skin. The Raman spectra were collected transcutaneously. Characteristic peaks of glucose (1125 cm-1) and hemoglobin (1549 cm-1) were observed. Hemoglobin concentration served as an internal standard, and the ratio of the peaks that appeared at 1125 cm-1 and 1549 cm-1 peaks was used to calculate the concentration of blood glucose. We studied three mouse subjects whose blood glucose levels became elevated over a period of 2 hours using a glucose test assay. During the test, 25 Raman spectra were collected transcutaneously and glucose reference values were provided by a blood glucose meter. Results clearly showed the relationship between Raman intensity and concentration. The release curves were approximately linear with a correlation coefficient of 0.91. This noninvasive methodology may be useful for the study of blood glucose in vivo.en_US
dc.identifier.citationPLoS ONE; 7:10 p. 1-6en_US
dc.identifier.doi10.1371/journal.pone.0048127
dc.identifier.issn1932-6203
dc.identifier.pmidpmc3485012en_US
dc.identifier.urihttp://hdl.handle.net/10342/5772
dc.relation.urihttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485012/en_US
dc.titleIn Vivo Blood Glucose Quantification Using Raman Spectroscopyen_US
dc.typeArticleen_US
ecu.journal.issue10en_US
ecu.journal.namePLoS ONEen_US
ecu.journal.pages1-6en_US
ecu.journal.volume7en_US

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