Effects of robotic-assisted laparoscopic prostatectomy on surgical pathology specimens

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dc.contributor.authorHong, Heng
dc.contributor.authorMel, Lin
dc.contributor.authorTaylor, Jonathan
dc.contributor.authorWu, Qiang
dc.contributor.authorReeves, Hugh
dc.date.accessioned2016-06-27T15:30:31Z
dc.date.available2016-06-27T15:30:31Z
dc.date.issued2012
dc.description.abstractBackground Robotic-assisted laparoscopic prostatectomy (RALP) has greatly changed clinical management of prostate cancer. It is important for pathologists and urologists to compare RALP with conventional open radical retropubic prostatectomy (RRP), and evaluate their effects on surgical pathology specimens. Methods We retrospectively reviewed and statistically analyzed 262 consecutive RALP (n = 182) and RRP (n = 80) procedures performed in our institution from 2007 to 2010. From these, 49 RALP and 33 RRP cases were randomly selected for additional microscopic examination to analyze the degree of capsular incision and the amount of residual prostate surface adipose tissue. Results Positive surgical margins were present in 28.6% RALP and 57.5% RRP cases, a statistically significant difference. In patients with stage T2c tumors, which represent 61.2% RALP and 63.8% RRP patients, the positive surgical margin rate was 24.1% in the RALP group and 58.8% in the RRP group (statistically significant difference). For other pathologic stages, the differences in positive margins between RALP and RRP groups were not statistically significant. The incidence of positive surgical margins after RALP was related to higher tumor stage, higher Gleason score, higher tumor volume and lower prostate weight, but was not related to the surgeons performing the procedure. When compared with RRP, RALP also caused less severe prostatic capsular incision and maintained larger amounts of residual surface adipose tissue in prostatectomy specimens. Conclusions In this study RALP showed a statistically significant lower positive surgical margin rate than RRP. Analysis of capsular incision and amount of prostatic surface residual adipose tissue suggested that RALP caused less prostatic capsular damage than RRP.en_US
dc.identifier.citationDiagnostic Pathology; 7: p. 24-24en_US
dc.identifier.doi10.1186/1746-1596-7-24
dc.identifier.issn1746-1596
dc.identifier.pmidpmc3313848en_US
dc.identifier.urihttp://hdl.handle.net/10342/5746
dc.relation.urihttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3313848/en_US
dc.subjectRobotic-assisted laparoscopic prostatectomyen_US
dc.subjectRadical retropubic prostatectomy,en_US
dc.subjectProstate canceren_US
dc.subjectPositive surgical marginen_US
dc.subjectCapsular incisionen_US
dc.titleEffects of robotic-assisted laparoscopic prostatectomy on surgical pathology specimensen_US
dc.typeArticleen_US
ecu.journal.nameDiagnostic Pathologyen_US
ecu.journal.pages24-24en_US
ecu.journal.volume7en_US

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