Ancient Genome Duplications Did Not Structure the Human Hox-Bearing Chromosomes

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dc.contributor.authorHughes, Austin L.en_US
dc.contributor.authorda Silva, Jacken_US
dc.contributor.authorFriedman, Roberten_US
dc.date.accessioned2011-04-29T13:10:28Zen_US
dc.date.accessioned2011-05-17T14:35:33Z
dc.date.available2011-04-29T13:10:28Zen_US
dc.date.available2011-05-17T14:35:33Z
dc.date.issued2001-05en_US
dc.description.abstractThe fact that there are four homeobox (Hox) clusters in most vertebrates but only one in invertebrates is often cited as evidence for the hypothesis that two rounds of genome duplication by polyploidization occurred early in vertebrate history. In addition, it has been observed in humans and other mammals that numerous gene families include paralogs on two or more of the four Hox-bearing chromosomes (the chromosomes bearing the Hox clusters; i.e., human chromosomes 2, 7, 12, and 17), and the existence of these paralogs has been taken as evidence that these genes were duplicated along with the Hox clusters by polyploidization. We tested this hypothesis by phylogenetic analysis of 42 gene families including members on two or more of the human Hox-bearing chromosomes. In 32 of these families there was evidence against the hypothesis that gene duplication occurred simultaneously with duplication of the Hox clusters. Phylogenies of 14 families supported the occurrence of one or more gene duplications before the origin of vertebrates, and of 15 gene duplication times estimated for gene families evolving in a clock-like manner, only six were dated to the same time period early in vertebrate history during which the Hox clusters duplicated. Furthermore, of gene families duplicated around the same time as the Hox clusters, the majority showed topologies inconsistent with their having duplicated simultaneously with the Hox clusters. The results thus indicate that ancient events of genome duplication, if they occurred at all, did not play an important role in structuring the mammalian Hox-bearing chromosomes. Originally published Genome Research, Vol. 11, No. 5, May 2001en_US
dc.identifier.citationGenome Research; 11:5 p. 771-780en_US
dc.identifier.doi10.1101/gr.160001
dc.identifier.pmidPMC311105en_US
dc.identifier.urihttp://hdl.handle.net/10342/3445en_US
dc.language.isoen_USen_US
dc.publisherEast Carolina Universityen_US
dc.relation.urihttp://genome.cshlp.org/content/11/5/771.full.pdf+htmlen_US
dc.rightsAuthor notified of opt-out rights by Cammie Jennings prior to upload of this article.en_US
dc.subjectGenome duplicationen_US
dc.subjectHox genesen_US
dc.subjectPhylogenetic analysisen_US
dc.titleAncient Genome Duplications Did Not Structure the Human Hox-Bearing Chromosomesen_US
dc.typeArticleen_US
ecu.journal.issue5
ecu.journal.nameGenome Research
ecu.journal.pages771-780
ecu.journal.volume11

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