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A depauperate immune repertoire precedes evolution of sociality in bees

dc.contributor.authorBarribeau, Seth M.
dc.contributor.authorSadd, Ben M.
dc.contributor.authordu Plessis, Louis
dc.contributor.authorBrown, Mark J. F.
dc.contributor.authorBuechel, Severine D.
dc.contributor.authorCappelle, Kaat
dc.contributor.authorCarolan, James C.
dc.contributor.authorChristiaens, Olivier
dc.contributor.authorColgan, Thomas J.
dc.contributor.authorErler, Silvio
dc.contributor.authorEvans, Jay D.
dc.contributor.authorHelbing, Sophie
dc.contributor.authorKaraus, Elke
dc.contributor.authorLattorff, H. M. G.
dc.contributor.authorMarxer, Monika
dc.contributor.authorMeeus, Ivan
dc.contributor.authorNäpflin, Kathrin
dc.contributor.authorNiu, Jinzhi
dc.contributor.authorSchmid-Hempel, Regula
dc.contributor.authorSmagghe, Guy
dc.contributor.authorWaterhouse, Robert M.
dc.contributor.authorYu, Na
dc.contributor.authorZdobnov, Evgeny M.
dc.contributor.authorSchmid-Hempel, Paul
dc.date.accessioned2016-02-16T21:24:09Z
dc.date.available2016-02-16T21:24:09Z
dc.date.issued2015-04-24
dc.date.updated2016-02-10T11:09:38Z
dc.description.abstractBackground Sociality has many rewards, but can also be dangerous, as high population density and low genetic diversity, common in social insects, is ideal for parasite transmission. Despite this risk, honeybees and other sequenced social insects have far fewer canonical immune genes relative to solitary insects. Social protection from infection, including behavioral responses, may explain this depauperate immune repertoire. Here, based on full genome sequences, we describe the immune repertoire of two ecologically and commercially important bumblebee species that diverged approximately 18 million years ago, the North American Bombus impatiens and European Bombus terrestris. Results We find that the immune systems of these bumblebees, two species of honeybee, and a solitary leafcutting bee, are strikingly similar. Transcriptional assays confirm the expression of many of these genes in an immunological context and more strongly in young queens than males, affirming Bateman’s principle of greater investment in female immunity. We find evidence of positive selection in genes encoding antiviral responses, components of the Toll and JAK/STAT pathways, and serine protease inhibitors in both social and solitary bees. Finally, we detect many genes across pathways that differ in selection between bumblebees and honeybees, or between the social and solitary clades. Conclusions The similarity in immune complement across a gradient of sociality suggests that a reduced immune repertoire predates the evolution of sociality in bees. The differences in selection on immune genes likely reflect divergent pressures exerted by parasites across social contexts.en_US
dc.identifier.citationGenome Biology. 2015 Apr 24;16(1):83en_US
dc.identifier.doi10.1186/s13059-015-0628-y
dc.identifier.issn1465-6906
dc.identifier.pmidpmc4408586
dc.identifier.urihttp://hdl.handle.net/10342/5210
dc.language.isoen_USen_US
dc.language.rfc3066en
dc.relation.urihttp://genomebiology.biomedcentral.com/articles/10.1186/s13059-015-0628-yen_US
dc.rights.holderBarribeau et al.; licensee BioMed Central.
dc.subjectBombus impatiensen_US
dc.subjectBombus terrestrisen_US
dc.subjectBumblebeesen_US
dc.subjectImmune responseen_US
dc.subjectGene expressionen_US
dc.subjectGenetic selectionen_US
dc.subjectSocial behavioren_US
dc.titleA depauperate immune repertoire precedes evolution of sociality in beesen_US
dc.typeArticleen_US
ecu.journal.issue1en_US
ecu.journal.nameGenome Biologyen_US
ecu.journal.pages83en_US
ecu.journal.volume16en_US

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