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Coarse Particulate Matter (PM2.5 - 10) Affects Heart Rate Variability, Blood Lipids, and Circulating Eosinophils in Adults with Asthma

dc.contributor.authorYeatts, Karinen_US
dc.contributor.authorSvendsen, Eriken_US
dc.contributor.authorCreason, Johnen_US
dc.contributor.authorAlexis, Neil E.en_US
dc.contributor.authorHerbst, Margaret C.en_US
dc.contributor.authorScott, Jamesen_US
dc.contributor.authorKupper, Lawrenceen_US
dc.contributor.authorWilliams, Ronald W.en_US
dc.contributor.authorNeas, Lucas M.en_US
dc.contributor.authorCascio, Wayne E.en_US
dc.contributor.authorDevlin, Robert B.en_US
dc.contributor.authorPeden, David B.en_US
dc.date.accessioned2011-01-27T16:33:15Zen_US
dc.date.accessioned2011-05-17T00:09:40Z
dc.date.available2011-01-27T16:33:15Zen_US
dc.date.available2011-05-17T00:09:40Z
dc.date.issued2007-05en_US
dc.description.abstractINTRODUCTION: We investigated whether markers of airway and systemic inflammation, as well as heart rate variability (HRV) in asthmatics, change in response to fluctuations in ambient particulate matter (PM) in the coarse [PM with aerodynamic diameter 2.5 - 10 micrometer (PM2.5 - 10)] and fine (PM2.5) size range. METHODS: Twelve adult asthmatics, living within a 30-mile radius of an atmospheric monitoring site in Chapel Hill, North Carolina, were followed over a 12-week period. Daily PM2.5 - 10 and PM2.5 concentrations were measured separately for each 24-hr period. Each subject had nine clinic visits, at which spirometric measures and peripheral blood samples for analysis of lipids, inflammatory cells, and coagulation-associated proteins were obtained. We also assessed HRV [SDNN24HR (standard deviation of all normal-to-normal intervals in a 24-hr recording), ASDNN5 (mean of the standard deviation in all 5-min segments of a 24-hr recording)] with four consecutive 24-hr ambulatory electrocardiogram measurements. Linear mixed models with a spatial covariance matrix structure and a 1-day lag were used to assess potential associations between PM levels and cardiopulmonary end points. RESULTS: For a 1-microgram/m3 increase in coarse PM, SDNN24HR, and ASDNN5 decreased 3.36% (p = 0.02), and 0.77%, (p = 0.05) respectively. With a 1-microgram/m3 increase in coarse PM, circulating eosinophils increased 0.16% (p = 0.01), triglycerides increased 4.8% (p = 0.02), and very low-density lipoprotein increased 1.15% (p = 0.01). No significant associations were found with fine PM, and none with lung function. CONCLUSION: These data suggest that small temporal increases in ambient coarse PM are sufficient to affect important cardiopulmonary and lipid parameters in adults with asthma. Coarse PM may have underappreciated health effects in susceptible populations. Originally published Environmental Health Perspectives, Vol. 115, No. 5, May 2007en_US
dc.identifier.citationEnvironmental Health Perspectives; 115:5 p. 709-714en_US
dc.identifier.doi10.1289/ehp.9499
dc.identifier.pmidPMC1867980en_US
dc.identifier.urihttp://hdl.handle.net/10342/3105en_US
dc.language.isoen_USen_US
dc.publisherEast Carolina Universityen_US
dc.relation.urihttp://ehp03.niehs.nih.gov/article/info%3Adoi%2F10.1289%2Fehp.9499en_US
dc.rightsAuthor notified of opt-out rights by Cammie Jennings prior to upload of this article.en_US
dc.subjectAsthmaen_US
dc.subjectCoarse PMen_US
dc.subjectHeart rate variabilityen_US
dc.subjectInflammatory markersen_US
dc.subjectLipidsen_US
dc.subjectSystemic inflammationen_US
dc.titleCoarse Particulate Matter (PM2.5 - 10) Affects Heart Rate Variability, Blood Lipids, and Circulating Eosinophils in Adults with Asthmaen_US
dc.typeArticleen_US
ecu.journal.issue5
ecu.journal.nameEnvironmental Health Perspectives
ecu.journal.pages709-714
ecu.journal.volume115

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