Emerging role of immune checkpoint blockade in pancreatic cancer

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dc.contributor.authorMacherla, S.
dc.contributor.authorLaks, S.
dc.contributor.authorNaqash, Abdul R.
dc.contributor.authorBulumulle, Anushi
dc.contributor.authorZervos, E.
dc.contributor.authorMuzaffar, Mahvish
dc.date.accessioned2019-06-20T19:06:31Z
dc.date.available2019-06-20T19:06:31Z
dc.date.issued2018-11-07
dc.description.abstractImmune checkpoint blockade (ICB) with programmed cell death protein-1(PD-1)/programmed death ligand -1(PD-L1) antibodies has revolutionized the management of several cancers, especially non-small cell lung cancer, melanoma, urothelial, and renal cancer. Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers associated with high morbidity and mortality. Based on available data, it's obvious that ICB has limited success in PDACs, which can be explained by the low immunogenicity and immunosuppressive tumor microenvironment of these tumors. In this review article, we focus on PD-L1 expression and microsatellite instability (MSI) in PDAC, and their roles as prognostic and predictive markers. We also discuss data supporting combination therapies to augment cancer immunity cycle. Combining anti-PD-1/PD-L1 agents with other modalities such as vaccines, chemotherapy, and radiation could potentially overcome resistance patterns and increase immune responsiveness in PDAC.en_US
dc.description.sponsorshipECU Open Access Publishing Support Funden_US
dc.identifier.citationMacherla, S., Laks, S., Naqash, A. R., Bulumulle, A., Zervos, E., & Muzaffar, M. (2018). Emerging role of immune checkpoint blockade in pancreatic cancer. International Journal of Molecular Sciences, 19(11) doi:10.3390/ijms19113505en_US
dc.identifier.doi10.3390/ijms19113505
dc.identifier.otherPMC6274962
dc.identifier.pmid30405053en_US
dc.identifier.urihttp://hdl.handle.net/10342/7355
dc.language.isoen_USen_US
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pubmed/30405053en_US
dc.subjectmicrosatellite instabilityen_US
dc.subjectpancreatic adenocarcinomaen_US
dc.subjectprogrammed death liganden_US
dc.titleEmerging role of immune checkpoint blockade in pancreatic canceren_US
dc.typeArticleen_US
ecu.journal.issue11en_US
ecu.journal.nameInternational Journal of Molecular Sciencesen_US
ecu.journal.volume19en_US

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