Orphan Glutamate Receptor delta-1 Subunit Required for High-Frequency Hearing

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dc.contributor.authorGao, Jiangangen_US
dc.contributor.authorMaison, Stephane F.en_US
dc.contributor.authorWu, Xudongen_US
dc.contributor.authorHirose, Keikoen_US
dc.contributor.authorJones, Sherri M.en_US
dc.contributor.authorBayazitov, Ildaren_US
dc.contributor.authorTian, Yongen_US
dc.contributor.authorMittleman, Guyen_US
dc.contributor.authorMatthews, Douglas B.en_US
dc.contributor.authorZakharenko, Stanislav S.en_US
dc.contributor.authorLiberman, M. Charlesen_US
dc.contributor.authorZuo, Jianen_US
dc.date.accessioned2011-03-02T19:54:35Zen_US
dc.date.accessioned2011-05-17T13:45:06Z
dc.date.available2011-03-02T19:54:35Zen_US
dc.date.available2011-05-17T13:45:06Z
dc.date.issued2007-06en_US
dc.description.abstractThe function of the orphan glutamate receptor delta subunits (GluR 1 and GluR 2) remains unclear. GluR 2 is expressed exclusively in the Purkinje cells of the cerebellum, and GluR 1 is prominently expressed in inner ear hair cells and neurons of the hippocampus. We found that mice lacking the GluR 1 protein displayed significant cochlear threshold shifts for frequencies of >16 kHz. These deficits correlated with a substantial loss of type IV spiral ligament fibrocytes and a significant reduction of endolymphatic potential in high-frequency cochlear regions. Vulnerability to acoustic injury was significantly enhanced; however, the efferent innervation of hair cells and the classic efferent inhibition of outer hair cells were unaffected. Hippocampal and vestibular morphology and function were normal. Our findings show that the orphan GluR 1 plays an essential role in high-frequency hearing and ionic homeostasis in the basal cochlea, and the locus encoding GluR 1 represents a candidate gene for congenital or acquired high-frequency hearing loss in humans. Originally published Molecular and Cellular Biology, Vol. 27, No. 12, June 2007en_US
dc.identifier.citationMolecular and Cellular Biology; 27:12 p. 4500-4512en_US
dc.identifier.doi10.1128/MCB.02051-06
dc.identifier.pmidPMC1900048en_US
dc.identifier.urihttp://hdl.handle.net/10342/3292en_US
dc.language.isoen_USen_US
dc.publisherEast Carolina Universityen_US
dc.relation.urihttp://mcb.asm.org/cgi/content/abstract/27/12/4500en_US
dc.rightsAuthor notified of opt-out rights by Cammie Jennings.en_US
dc.subjectOrphan glutamate receptoren_US
dc.subjectHigh-frequency hearing lossen_US
dc.subjectIonic homeostasisen_US
dc.subjectBasal cochleaen_US
dc.titleOrphan Glutamate Receptor delta-1 Subunit Required for High-Frequency Hearingen_US
dc.typeArticleen_US

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