Unusual reticulin staining pattern in well-differentiated hepatocellular carcinoma

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dc.contributor.authorHong, Heng
dc.contributor.authorPatonay, Bryan
dc.contributor.authorFinley, James
dc.date.accessioned2016-06-27T15:24:17Z
dc.date.available2016-06-27T15:24:17Z
dc.date.issued2011
dc.description.abstractBackground Special stains, such as reticulin stain and CD34 immunostain, are very helpful in the diagnosis of well differentiated hepatocellular carcinoma (HCC). Most studies have shown that absent or decreased reticulin stain or an abnormal reticulin pattern with widened trabeculae is reliable for the diagnosis of well-differentiated HCC. Case report We report here two cases of well differentiated HCC with an unusual reticulin staining pattern. A strongly positive reticulin network was preserved within the tumor, which surrounded individual tumor cells in a monolayered trabecular pattern. At the same time, an increased CD34 stain was present in the tumor. Conclusions This unusual reticulin pattern represents part of the diverse reticulin staining patterns seen in HCC. Although this staining pattern is rare, it should be recognized when diagnosing well-differentiated HCC in small samples such as cellblock of fine needle aspiration or small core biopsies.en_US
dc.identifier.citationDiagnostic Pathology; 6: p. 15-15en_US
dc.identifier.doi10.1186/1746-1596-6-15
dc.identifier.issn1746-1596
dc.identifier.pmidpmc3049127en_US
dc.identifier.urihttp://hdl.handle.net/10342/5743
dc.relation.urihttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049127/en_US
dc.titleUnusual reticulin staining pattern in well-differentiated hepatocellular carcinomaen_US
dc.typeArticleen_US
ecu.journal.nameDiagnostic Pathologyen_US
ecu.journal.pages15-15en_US
ecu.journal.volume6en_US

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