Racial difference in Acylation Stimulating Protein (ASP) correlates to triglyceride in non-obese and obese African American and Caucasian women

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dc.contributor.authorScantlebury-Manning, Theaen_US
dc.contributor.authorBower, Joseph F.en_US
dc.contributor.authorCianflone, Katherineen_US
dc.contributor.authorBarakat, Hisham A.en_US
dc.date.accessioned2011-04-28T17:42:18Zen_US
dc.date.accessioned2011-05-17T01:27:03Z
dc.date.available2011-04-28T17:42:18Zen_US
dc.date.available2011-05-17T01:27:03Z
dc.date.issued2009-04-17en_US
dc.description.abstractBackground: Acylation Stimulating Protein (ASP) has been shown to influence adipose tissue triglyceride (TG) storage. The aim was to examine ethnic differences in ASP and leptin levels in relation to lipid profiles and postprandial changes amongst African American (AA) and Caucasian American (CA) women matched for BMI. Methods: 129 women were recruited in total (age 21 – 73 y): 24 non-obese (BMI < 30 kg/m2) CA, 27 obese (BMI ≥ 30 kg/m2) CA, 13 obese diabetic CA, 25 non-obese AA, 25 obese AA, and 15 obese diabetic AA. Cholesterol, HDL-C, LDL-C, apoB, glucose and insulin were measured at baseline. TG, non-esterified fatty acids, leptin, and ASP were measured at baseline and postprandially following a fat meal. Results: ASP, leptin, insulin and TG were significantly increased in obese subjects within each race. However, AA women had significantly lower ASP and TG than CA women at all BMI. Obese and diabetic AA women had significantly lower apoB levels than CA women when compared to their respective counterparts. For AA women, fasting ASP was positively correlated with BMI, cholesterol, apoB, LDL-C and glucose. For CA women, fasting ASP was positively correlated with BMI, leptin, glucose and insulin. However, for any given BMI, ASP was significantly reduced in AA vs CA (p = 0.0004). Similarly, for any given leptin level or TG levels, ASP was significantly lower in AA women (p = 0.041 and p = 0.003, respectively). Conclusion: CA women have higher baseline TG levels and an earlier TG peak that is accompanied with higher ASP levels suggesting increased ASP resistance, while AA women have lower baseline TG levels and a later TG peak at lower ASP levels suggesting increased ASP sensitivity. This may explain why AA women may have fewer metabolic complications, such as diabetes and CVD, when compared to their Caucasian counterparts at the same level of obesity. Originally published Nutrition and Metabolism, Vol. 6, No. 18, Apr 2009en_US
dc.identifier.citationNutrition and Metabolism; 6:18 p. 1-9en_US
dc.identifier.pmidPMC2679015en_US
dc.identifier.urihttp://hdl.handle.net/10342/3397en_US
dc.language.isoen_USen_US
dc.publisherEast Carolina Universityen_US
dc.relation.urihttp://www.nutritionandmetabolism.com/content/6/1/18en_US
dc.rightsAuthor notified of opt-out rights by Cammie Jennings prior to upload of this article.en_US
dc.subjectAcylation stimulating proteinen_US
dc.subjectTrigylceride storageen_US
dc.subjectRacial differencesen_US
dc.titleRacial difference in Acylation Stimulating Protein (ASP) correlates to triglyceride in non-obese and obese African American and Caucasian womenen_US
dc.typeArticleen_US

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