Distortion Product Otoacoustic Emissions in Normal-Hearing Children with Homozygous Sickle Cell Disease

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dc.contributor.authorHolbert, Donalden_US
dc.contributor.authorDowns, C. ReneƩen_US
dc.contributor.authorStuart, Andrewen_US
dc.date.accessioned2008-07-21T14:49:54Zen_US
dc.date.accessioned2009-08-07T14:26:31Zen_US
dc.date.accessioned2011-05-17T13:45:08Z
dc.date.available2008-07-21T14:49:54Zen_US
dc.date.available2009-08-07T14:26:31Zen_US
dc.date.available2011-05-17T13:45:08Z
dc.date.issued2003en_US
dc.description.abstractThe purpose of this study was to investigate distortion product otoacoustic emissions (DPOAEs) in young normal-hearing children with sickle cell disease (SCD). It was hypothesized that the prevalence of DPOAEs and response amplitudes would be lower than those in children with normal hemoglobin due to suspected compromised cochlear function as a result of vaso-occlusive events characteristic of SCD. Twenty African-American children with SCD and 15 African-American children with normal hemoglobin participated. Distortion product OAEs were evoked by thirteen primary tone pairs with f2 frequencies ranging from 1000 to 4500 Hz. The primary tones were presented at and L1 and L2 levels of 70 and 60 dB SPL (high) and 50 and 40 dB SPL (low), respectively. The findings of this study were completely unexpected and contrary to our original hypotheses. The likelihood of detecting a DPOAE response was not related to the clinical status of the children. Distortion product OAE amplitudes were significantly larger for children with SCD (p = .01). Educational Objectives: After completing this article the reader will (1) have a basic knowledge of the audiometric complications of sickle cell disease and (2) appreciate the differences in DPOAEs between young normal-hearing children with sickle cell DPOAEs in Children With Sickle Cell Disease 3 disease and young normal-hearing children with normal hemoglobin.en_US
dc.format.extent33 p.en_US
dc.identifier.citationAmerican Auditory Society Bulletin; 24:1 p. 20en_US
dc.identifier.doi10.1016/S0021-9924(99)00027-1
dc.identifier.urihttp://hdl.handle.net/10342/1097en_US
dc.language.isoenen_US
dc.publisherEast Carolina Universityen_US
dc.subjectAuditory thresholdsen_US
dc.subjectAudiologyen_US
dc.subjectOtoacoustic emissionsen_US
dc.subjectSickle cell diseaseen_US
dc.subject.lcshSickle cell anemia in childrenen_US
dc.subject.lcshHearing disorders in childrenen_US
dc.subject.lcshHearing disordersen_US
dc.subject.meshAnemia, Sickle Cellen_US
dc.titleDistortion Product Otoacoustic Emissions in Normal-Hearing Children with Homozygous Sickle Cell Diseaseen_US
dc.title.alternativeDPOAEs in Children With Sickle Cell Diseaseen_US
dc.typeArticleen_US
ecu.journal.issue1
ecu.journal.nameAmerican Auditory Society Bulletin
ecu.journal.pages20
ecu.journal.volume24

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