Browsing by Author "Brown, Jared"
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Bone marrow stromal cells attenuate sepsis via prostaglandin E2— dependent reprogramming of host macrophages to increase their interleukin-10 production
Nemeth, Krisztian; Leelahavanichkul, Asada; Yuen, Peter S. T.; Mayer, Balazs; Parmelee, Alissa; Doi, Kent; Robey, Pamela G.; Leelahavanichkul, Kantima; Koller, Beverly H.; Brown, Jared; Hu, Xuzhen; Jelinek, Ivett; Star, Robert A.; Mezey, Eva (East Carolina University, 2009-01)Sepsis causes over 200,000 deaths yearly in the US; better treatments are urgently needed. Administering bone marrow stromal cells (BMSCs—also known as mesenchymal stem cells) to mice before or shortly after inducing sepsis ... -
Expansion of cardiac ischemia/reperfusion injury after instillation of three forms of multi-walled carbon nanotubes
Urankar, Rakhee N.; Lust, Robert M.; Mann, Erin; Katwa, Pranita; Wang, Xiaojia; Podila, Ramakrishna; Hilderbrand, Susana C.; Harrison, Benjamin S.; Chen, Pengyu; Ke, Pu Chun; Rao, Apparao M.; Brown, Jared; Wingard, Christopher J. (2012)Background The exceptional physical-chemical properties of carbon nanotubes have lead to their use in diverse commercial and biomedical applications. However, their utilization has raised concerns about human exposure ... -
Expansion of cardiac ischemia/reperfusion injury after instillation of three forms of multi-walled carbon nanotubes
Urankar, Rakhee N; Lust, Robert M; Mann, Erin; Katwa, Pranita; Wang, Xiaojia; Podila, Ramakrishna; Hilderbrand, Susana C; Harrison, Benjamin S; Chen, Pengyu; Ke, Pu Chun; Rao, Apparao M; Brown, Jared; Wingard, Christopher J (2012-10-16)Background The exceptional physical-chemical properties of carbon nanotubes have lead to their use in diverse commercial and biomedical applications. However, their utilization has raised concerns about human exposure that ... -
Interlaboratory Evaluation of Rodent Pulmonary Responses to Engineered Nanomaterials: The NIEHS Nano GO Consortium
Bonner, James C.; Silva, Rona M.; Taylor, Alexia J.; Brown, Jared; Hilderbrand, Susana C.; Castranova, Vincent; Porter, Dale; Elder, Alison; Oberdörster, Günter; Harkema, Jack R.; Bramble, Lori A.; Kavanagh, Terrance J.; Botta, Dianne; Nel, Andre; Pinkerton, Kent E. (2013-05)Background: Engineered nanomaterials (ENMs) have potential benefits, but they also present safety concerns for human health. Interlaboratory studies in rodents using standardized protocols are needed to assess ENM ... -
Intravenously delivered graphene nanosheets and multiwalled carbon nanotubes induce site-specific Th2 inflammatory responses via the IL-33/ST2 axis
Wang, Xiaojia; Podila, Ramakrishna; Shannahan, Jonathan H.; Rao, Apparao M.; Brown, Jared (2013)Carbon-based nanomaterials (CBN), such as graphene nanosheets (GNS) and multiwalled carbon nanotubes (MWCNT), have been proposed for potential nanomedicine applications such as biomedical devices and carriers for drug ... -
Intravenously delivered graphene nanosheets and multiwalled carbon nanotubes induce site-specific Th2 inflammatory responses via the IL-33/ST2 axis
Wang, Xiaojia; Podila, Ramakrishna; Shannahan, Jonathan H; Rao, Apparao M; Brown, Jared (2013-05-03)Carbon-based nanomaterials (CBN), such as graphene nanosheets (GNS) and multiwalled carbon nanotubes (MWCNT), have been proposed for potential nanomedicine applications such as biomedical devices and carriers for drug ... -
Mast cells and the IL-33/ST2 axis are essential determinants of carbon nanotube toxicity
Katwa, Pranita (East Carolina University, 2012)The rise of nanomaterial use in a variety of applications, including biomedical imaging and drug delivery, has led to concern about the potentially hazardous impacts on human health. Mast cells are critical for innate and ... -
Multi-walled carbon nanotube instillation impairs pulmonary function in C57BL/6 mice
Wang, Xiaojia; Katwa, Pranita; Podila, Ramakrishna; Chen, Pengyu; Ke, Pu Chun; Rao, Apparao M.; Walters, Dianne M.; Wingard, Christopher J.; Brown, Jared (2011)Background Multi-walled carbon nanotubes (MWCNTs) are widely used in many disciplines due to their unique physical and chemical properties. Therefore, some concerns about the possible human health and environmental ... -
Multi-walled carbon nanotube instillation impairs pulmonary function in C57BL/6 mice
Wang, Xiaojia; Katwa, Pranita; Podila, Ramakrishna; Chen, Pengyu; Chun Ke, Pu; Rao, Apparao M; Walters, Dianne M; Wingard, Christopher J; Brown, Jared (2011-08-18)Multi-walled carbon nanotubes (MWCNTs) are widely used in many disciplines due to their unique physical and chemical properties. Therefore, some concerns about the possible human health and environmental impacts of ... -
Pulmonary Exposure to Magnéli Phase Titanium Suboxides Results in Significant Macrophage Abnormalities and Decreased Lung Function
McDaniel, Dylan K.; Ringel-Scaia, Veronica M.; Morrison, Holly A.; Coutermarsh-Ott, Sheryl; Council-Troche, McAlister; Angle, Jonathan W.; Perry, Justin B.; Davis, Grace; Leng, Weinan; Minarchick, Valerie; Yang, Yi; Chen, Bo; Reece, Sky W.; Brown, David A.; Cecere, Thomas E.; Brown, Jared; Gowdy, Kymberly M.; Hochella, Michael F.; Allen, Irving C. (2019-11-28)Coal is one of the most abundant and economic sources for global energy production. However, the burning of coal is widely recognized as a significant contributor to atmospheric particulate matter linked to deleterious ...