Browsing by Author "Wingard, Christopher J."
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Augmented coronary vascular smooth muscle response to endothelin-1 exacerbates cardiac injury following pulmonary exposure to engineered nanomaterials
Thompson, Leslie Charles (East Carolina University, 2014)Multi-walled carbon nanotubes (MWCNT) and 60-carbon fullerenes (C60) are important engineered nanoparticles (ENP) used across industry. Exposure to ENP potentially promotes cardiovascular detriments. The hypotheses that ... -
Elevated MicroRNA-33 in Sarcoidosis and a Carbon Nanotube Model of Chronic Granulomatous Disease
Bowling, Mark R.; Barna, Barbara P.; McPeek, Matthew; Malur, Anagha; Wingard, Christopher J.; Dobbs, Larry; Verbanac, Kathryn M.; Thomassen, Mary Jane (2016-06-01) -
Expansion of cardiac ischemia/reperfusion injury after instillation of three forms of multi-walled carbon nanotubes
Urankar, Rakhee N.; Lust, Robert M.; Mann, Erin; Katwa, Pranita; Wang, Xiaojia; Podila, Ramakrishna; Hilderbrand, Susana C.; Harrison, Benjamin S.; Chen, Pengyu; Ke, Pu Chun; Rao, Apparao M.; Brown, Jared; Wingard, Christopher J. (2012)Background The exceptional physical-chemical properties of carbon nanotubes have lead to their use in diverse commercial and biomedical applications. However, their utilization has raised concerns about human exposure ... -
Identification, cloning and functional characterization of novel beta-defensins in the rat (Rattus norvegicus)
Yenugu, Suresh; Chintalgattu, Vishnu; Wingard, Christopher J.; Radhakrishnan, Yashwanth; French, Frank S.; Hall, Susan H. (East Carolina University, 2006-02-04)Background beta-defensins are small cationic peptides that exhibit broad spectrum antimicrobial properties. The majority of beta-defensins identified in humans are predominantly expressed in the male reproductive tract ... -
Impact of pulmonary exposure to gold core silver nanoparticles of different size and capping agents on cardiovascular injury
Holland, Nathan A.; Thompson, Leslie C.; Vidanapathirana, Achini K.; Urankar, Rahkee N.; Lust, Robert M.; Fennell, Timothy R.; Wingard, Christopher J. (2016-08-24)Background:The uses of engineered nanomaterials have expanded in biomedical technology and consumer manufacturing. Furthermore, pulmonary exposure to various engineered nanomaterials has, likewise, demonstrated the ability ... -
Intratracheal instillation of silver nanoparticles exacerbates cardiac ischemia/reperfusion injury in male sprague-dawley rats
Holland, Nathan A. (East Carolina University, 2014)The uses of engineered nanomaterials have expanded in biomedical technology and consumer manufacturing. Exposure to particulate matter has been demonstrated to negatively influence cardiovascular health and expand myocardial ... -
Multi-walled carbon nanotube instillation impairs pulmonary function in C57BL/6 mice
Wang, Xiaojia; Katwa, Pranita; Podila, Ramakrishna; Chen, Pengyu; Ke, Pu Chun; Rao, Apparao M.; Walters, Dianne M.; Wingard, Christopher J.; Brown, Jared (2011)Background Multi-walled carbon nanotubes (MWCNTs) are widely used in many disciplines due to their unique physical and chemical properties. Therefore, some concerns about the possible human health and environmental ... -
Novel role for thioredoxin reductase-2 in mitochondrial redox adaptations to obesogenic diet and exercise in heart and skeletal muscle
Fisher-Wellman, Kelsey H.; Mattox, Taylor A.; Thayne, Kathleen; Katunga, Lalage Adalaide; La Favor, Justin D.; Neufer, P. Darrell; Hickner, Robert C.; Wingard, Christopher J.; Anderson, Ethan (2013)Increased fatty acid availability and oxidative stress are physiological consequences of exercise (Ex) and a high-fat, high-sugar (HFHS) diet. Despite these similarities, the global effects of Ex are beneficial, whereas ... -
The role of PPARγ in carbon nanotube-elicited granulomatous lung inflammation
Huizar, Isham; Malur, Anagha; Patel, Janki; McPeek, Matthew; Dobbs, Larry; Wingard, Christopher J.; Barna, Barbara P.; Thomassen, Mary Jane (2013)BACKGROUND: Although granulomatous inflammation is a central feature of many disease processes, cellular mechanisms of granuloma formation and persistence are poorly understood. Carbon nanoparticles, which can be products ...