Browsing by Subject "Biology, Genetics"
Now showing items 1-20 of 21
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Are Marine Migrations of Striped Bass Genetically Pre-determined? : An investigation of Albemarle Sound-Roanoke River Striped Bass Migratory Patterns
(East Carolina University, 2010)Striped bass, Morone saxatilis, is one of the most thoroughly studied anadromous fish species in the United States, with records governing the management of the species dating back to the late 1600s. However, management ... -
Characterization of the GINS subunit psf1 in Drosophila Melanogaster
(East Carolina University, 2010)GINS (Go Ichi Ni San; 5,1,2,3 in Japanese) is a heterotetrameric protein complex known to be essential for the establishment of DNA replication forks and the progression of the replisome. The GINS complex is known to be ... -
Characterization of Two Novel Mutants of DNA Polymerase Delta in Drosophila melanogaster
(East Carolina University, 2011)DNA is the genetic material for all living organisms which is constantly being unpackaged, replicated and repackaged. The replication of this genetic material involves numerous different proteins; however, DNA polymerase ... -
Developing a Panel of Microsatellite Markers for Common Moorhen (Gallinula chloropus) as a Research Tool for Population Studies
(East Carolina University, 2013)The common moorhen (Gallinula chloropus) sometimes exhibits brood parasitism - a parent manipulating a conspecific host to raise its offspring, relieving the parent of the encumbrance of parental investment. It has been ... -
Drosophila Ctf4 is essential for genome stability and normal cell cycle progression
(East Carolina University, 2010)Proper DNA replication and well-timed cell cycle progression are vital to the normal functioning of a cell. Precise coordination between these mechanisms' constituent proteins ensures their processivity while safeguarding ... -
Drosophila Psf2 Has a Role In Chromosome Condensation
(East Carolina University, 2012)The condensation state of chromosomes is a critical parameter in multiple processes within the cell. Failures in the maintenance of appropriate condensation states may lead to genomic instability, mis-expression of genes, ... -
Effect of MicroRNA-34c on Regenerative Axon Growth in Dorsal Root Ganglion Neurons of the Peripheral Nervous System
(East Carolina University, 2011)The peripheral nervous system is unique in its ability to regenerate axons after injury. Our lab previously assessed the miRNA expression levels of the regenerating sciatic nerve which indicated miR-34c up-regulation. ... -
ESTABLISHING LINKAGE BETWEEN GINS COMPLEX SUB-UNIT Sld5 AND CHECKPOINT PROTEIN Chk2 (loki) USING DROSOPHILA MELANOGASTER AS MODEL ORGANISM
(East Carolina University, 2012)Eukaryotic DNA replication is controlled by a number of proteins that ensures the process takes place accurately. GINS, a hetero-tetrameric protein complex is known to be essential for the initiation and progression of ... -
THE EVOLUTION OFHOX [sic] PARALOG GROUP 2 GENE EXPRESSION AND REGULATION IN THE JAPANESE MEDAKA
(East Carolina University, 2011)Hox paralog group 2 (PG2) genes are evolutionarily conserved developmental regulatory genes that function to specify rhombomere (r) and pharyngeal arch (PA) identities in animal embryos. Several rounds of whole genome ... -
HIGHER-LEVEL SYSTEMATICS OF THE MILLIPEDES (ARTHROPODA: MYRIAPODA: DIPLOPODA) EVALUATED USING TRANSCRIPTOMIC DATA, MITOCHONDRIAL GENOMICS, AND CLASSIFICATION ANALYSES
(East Carolina University, 2012)Knowledge of deep level phylogenetic relationships within and between many animal groups is currently lacking. Past attempts to reconstruct these ancient evolutionary relationships once relied chiefly on morphological ... -
Hox Gene Expression During Oreochromis niloticus Pharyngeal Arch Development : Discovering the Hox Code
(East Carolina University, 2010)Hox genes encode transcription factors and have been extensively studied by evolutionary and developmental biologists. Hox genes are responsible for determining specific regional identities along the anterior-posterior and ... -
Interaction and Functional Analysis of Drosophila Mcm10
(East Carolina University, 2010)In eukaryotic cells, DNA replication and the subsequent packaging of DNA into specific chromatin states are essential processes for the transmission of genetic material and genomic stability which may be linked by interactions ... -
Investigations into the roles of bacteroides fragilis thioredoxins during the oxidative stress response
(East Carolina University, 2011)The Gram-negative Bacteroides fragilis is the most frequently isolated bacterium from anaerobic infections. Native to the human intestinal tract, it serves a symbiotic role breaking down complex polysaccharides and ... -
Metabolic Inflexibility in Response to Lipid Oversupply with Obesity: Epigenetic Modifications Play a Role
(East Carolina University, 2013)The ability to adjust substrate oxidation according to nutrient availability has been termed `metabolic flexibility' and is a critical factor in overall metabolic health. In respect to fatty acid oxidation (FAO) metabolic ... -
MHC class I variation among wild, domestic and insular populations of the zebra finch (Taeniopygia guttata)
(East Carolina University, 2014)The zebra finch (Taeniopygia guttata) is a passerine bird native to Australia and the Lesser Sunda Islands, with domesticated populations derived from each of these localities. The Lesser Sundas and domesticated zebra ... -
p53 and NGAL: dual regulatory roles in advanced prostate cancer
(East Carolina University, 2011)The development of prostate cancer from small regions of hyperplasia to invasive tumors requires genetic and epigenetic alterations of critical cellular components to aid in the development of cells more adapted for aberrant ... -
PARSING POLYPHYLETIC PUERARIA : DELIMITING DISTINCT EVOLUTIONARY LINEAGES THROUGH PHYLOGENY
(East Carolina University, 2013)A taxon is defined as polyphyletic when it does not include the last common ancestor of all true members of the taxon, resulting in a number of subgroups not united by a common ancestor. Previous work has suggested Pueraria ... -
Paternal diet and exercise epigenetically program energy expenditure and glucose metabolism in mouse offspring
(East Carolina University, 2014)It is currently estimated that a third of Americans suffer from metabolic syndrome, which is an obesogenic disease shown to increase risk for developing type 2 diabetes (T2DM) by five-fold (Diabetes Care, 2012). The ... -
A Quantitative Survey of Gravity Receptor Function in Mutant Mouse Strains
(East Carolina University, 2005-12)The purpose of this research was to identify vestibular deficits in mice using linear vestibular evoked potentials (VsEPs). VsEP thresholds, peak latencies, and peak amplitudes from 24 strains with known genetic mutations ... -
Transcriptional Analysis of the Bacteroides fragilis Starch Utilization Operon, osuA
(East Carolina University, 2011)The opportunistic pathogen Bacteroides fragilis is a symbiotic organism that inhabits the human gastrointestinal tract where it utilizes dietary and host-derived polysaccharides as carbon and energy sources. If abdominal ...