Browsing Physiology by Author "Virag, Jitka A. I."
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Anatomical-Molecular Distribution of EphrinA1 in Infarcted Mouse Heart Using MALDI Mass Spectrometry Imaging
Lefcoski, Stephan; Kew, Kimberly; Reece, Shaun; Torres, Maria J.; Parks, Justin C.; de Castro Brás, Lisandra E.; Virag, Jitka A. I. (2018-01-05)EphrinA1 is a tyrosine kinase receptor localized in the cellular membrane of healthy cardiomyocytes, the expression of which is lost upon myocardial infarction (MI). Intra-cardiac injection of the recombinant form of ... -
Circadian influences on myocardial infarction
Virag, Jitka A. I.; Lust, Robert M. (2014-10-30)Components of circadian rhythm maintenance, or “clock genes,” are endogenous entrainable oscillations of about 24 h that regulate biological processes and are found in the suprachaismatic nucleus (SCN) and many peripheral ... -
Coronary Artery Ligation and Intramyocardial Injection in a Murine Model of Infarction
Virag, Jitka A. I.; Lust, Robert M. (2011)Mouse models are a valuable tool for studying acute injury and chronic remodeling of the myocardium in vivo. With the advent of genetic modifications to the whole organism or the myocardium and an array of biological and/or ... -
Deletion of the EphA2 receptor exacerbates myocardial injury and the progression of ischemic cardiomyopathy
O'Neal, Wesley T.; Griffin, William F.; Kent, Susan D.; Faiz, Filza; Hodges, Jonathan; Vuncannon, Jackson; Virag, Jitka A. I. (2014-04)EphrinA1-EphA-receptor signaling is protective during myocardial infarction (MI). The EphA2-receptor (EphA2-R) potentially mediates cardiomyocyte survival. To determine the role of the EphA2-R in acute non-reperfused ... -
EphA2-receptor deficiency exacerbates myocardial infarction and reduces survival in hyperglycemic mice
DuSablon, Augustin; Kent, Susan D.; Coburn, Anita; Virag, Jitka A. I. (2014-08)Background We have previously shown that EphrinA1/EphA expression profile changes in response to myocardial infarction (MI), exogenous EphrinA1-Fc administration following MI positively influences wound healing, and ... -
Molecular Histology of EphrinA1 Expression in Mouse Heart Visualized Molecular Histology of EphrinA1 Expression in Mouse Heart Visualized with MALDI-MSI
Parks, Justin C. (East Carolina University, 2018-07-25)EphrinA1 is a tyrosine kinase receptor localized in the cellular membrane of healthy cardiomyocytes, the expression of which is lost upon myocardial infarction (MI). Intra-cardiac injection of the recombinant form of ... -
The Dopamine D3 Receptor Knockout Mouse Mimics Aging-Related Changes in Autonomic Function and Cardiac Fibrosis
Johnson, Tracy L.; Tulis, David A.; Keeler, Benjamin E.; Virag, Jitka A. I.; Lust, Robert M.; Clemens, Stefan (2013-) -
Tissue Salvage in the Non-reperfused Myocardium Mediated by (the absence of the circadian rhythm gene) mPer2 and (the receptor tyrosine kinase) EphrinA1
Dries, Jessica L. (East Carolina University, 2010)Alterations in circadian rhythm have been associated with numerous cardiovascular pathologies. In project 1, we tested the hypothesis that functional mutation of the Per2 circadian clock gene would provide cardioprotection ...