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Now showing items 11-20 of 93
Repair of Clustered DNA Lesions in Double Strand Break Repair Deficient Human Tumor Cells
(East Carolina University, 2010)
DNA-dependent protein kinase (DNA-PK) is a holoenzyme of three subunits, Ku70, Ku80, and the DNA-Pk catalytic subunit (DNA-PKcs). DNA-PK serves a role in non-homologous end joining to repair double stranded breaks, and ...
Physiological and Phylogenetic Studies of the Biogeography of Alkaliphilic Heterotrophic Bacteria from Serpentinizing Habitats
(East Carolina University, 2014)
Serpentinization occurs when ultramafic rocks containing the mineral olivine react with water to produce highly reducing conditions, which are commonly coincident with high concentrations of hydrogen. Hydrogen provides ...
Analysis of scn5Laa and scn5Lab Gene Function in Danio rerio (Zebrafish) Heart Development through TALENs/CRISPR-CAS9-mediated Gene Knockout
(East Carolina University, 2015)
Research in our laboratory is focused on understanding the molecular developmental genetic effects of crude oil exposure on vertebrate embryogenesis. Our research has demonstrated that exposure of zebrafish embryos to ...
Inhibitory and oxidative effects of gossypol on MCF7 Breast Cancer cells in vitro
(East Carolina University, 2013)
Human cancer is the second leading cause of death in the United States and breast cancer is responsible for the second highest number of deaths in women with cancer worldwide. Today, cancer is becoming more and more ...
The Evolution of Organ Shape : Distal Tip Cell Migration and Gonadogenesis in Nematodes
(East Carolina University, 2013)
Animals display a variety of shapes in nature. The different shape of homologous organs allows them to adopt different functions and therefore, allows animals to live in different ecological niches. However, little is ...
Characterization of the Role of Mcm10 in DNA Replication in Drosophila melanogaster
(East Carolina University, 2013)
Replication of the genome and proper formation, and packaging, of chromatin are processes essential to eukaryotic life. Maintenance of epigenetic chromatin states is essential for faithfully reproducing the transcriptional ...
Responses of Leaf Litter Breakdown Rates and Microbial Enzyme Activity to Salinity in North Carolina Wetlands
(East Carolina University, 2014)
Sea-level rise and human activities are causing the increase of salinity in coastal freshwater wetlands. Increased salinity in some wetlands has been found to accelerate leaf litter decomposition, an important driver of ...
USING LASER CAPTURE MICRODISSECTION (LCM) TO EXAMINE MADS-BOX GENE EXPRESSION IN THE UPPER AND LOWER FLORAL MERISTEMS OF MAIZE
(East Carolina University, 2013)
MADS-box transcription factors are important regulators of flower development in all flowering plants. In the grasses, flowers (called florets) are contained in spikelets. Maize spikelets contain two florets (the upper and ...
Rectifying Limitations On Species Delineation In Dusky Salamanders : Lineage Detection Using An Ecoregion-Drainage Sampling Regime
(East Carolina University, 2015)
The dusky salamanders (Desmognathus) constitute a large, species-rich group, and although a considerable body of literature exists on systematic relationships and adaptive trends, these issues have heretofore been approached ...
Metabolic, Physiological, And Behavioral Responses Of Prey To Predation
(East Carolina University, 2015)
Predators are known to cause prey to alter their morphology, life history or behavior in ways that reduce the likelihood of the prey being consumed by the predator. Seldom considered, however, are the consequences of ...