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Intron position in RNA polymerase genes and their relationship to eukaryotic phylogenies
(East Carolina University, 2010)
Over the past two decades, there has been an increasing amount of research devoted to the study of intron evolution and its relationship to eukaryotic phylogeny. Previous studies have shown that a large percentage of ...
Modulation of IKKβ with AMPK Improves Insulin Sensitivity in Skeletal Muscle
(East Carolina University, 2008-11)
Activation of the insulin receptor substrate (IRS)-1 is necessary for proper transduction of the insulin signal. IRS-1 serine312(human)/307(rodent) phosphorylation, however, results in disruption of this signal and subsequent ...
Characterization of Two Novel Mutants of DNA Polymerase Delta in Drosophila melanogaster
(East Carolina University, 2011)
DNA is the genetic material for all living organisms which is constantly being unpackaged, replicated and repackaged. The replication of this genetic material involves numerous different proteins; however, DNA polymerase ...
Effect of Versican G1 Domain Overexpression on Hyaluronan, Hyaluronidase-2, and Synovial Joint Formation in the Embryonic Chick
(East Carolina University, 2013)
Versican, an extracellular chondroitin sulfate proteoglycan which binds hyaluronan, has been hypothesized to play a role in synovial joint formation in the chick embryo. Several studies have shown versican to be involved ...
Lateral Gene Transfer between Bacteria and Trichoderma reesei
(East Carolina University, 2012)
Lateral gene transfer (LGT) has played an important role in shaping the `tree of life'. It has promoted evolution by generating gene redundancies, which allow for more freedom in terms of allowed mutations in a genome, ...
Analysis of Complex DNA Damage Associated with Tumor Growth
(East Carolina University, 2012)
The innate response of a fully functioning immune system's ability to recognize and react to the growth of a tumor by releasing reactive oxygen species (ROS) may lead to chronic inflammation in many cases. This chronic ...
River Herring Nursery Habitat in Albemarle Sound, North Carolina, Inferred from Otolith Microchemistry
(East Carolina University, 2012)
River herring is a collective term used to describe two similar alosine species: alewife Alosa pseudoharengus and blueback herring A. aestivalis. Both of these anadromous species are native to the Atlantic coast of North ...
RESPONSE OF A SPARTINA PATENS-DOMINATED OLIGOHALINE MARSH TO NITROGEN ENRICHMENT IN COASTAL NORTH CAROLINA, USA.
(East Carolina University, 2013)
Coastal marshes are highly productive ecosystems that play a significant role in the global carbon budget. Anthropogenic alterations to coastal landscapes can significantly impact these marsh ecosystems, though the actual ...
Claudin-7 increases chemosensitivity to cisplatin in human NCI-H522 lung cancer cells
(East Carolina University, 2010)
Lung cancer is a leading cause of cancer death for both men and women worldwide. The 5-year survival rate for lung cancer is only 15%, and it accounts for approximately 1.4 million deaths every year. Recently, it has ...
Hybridization in two subspecies of triodanis perfoliata, a cleistogamous annual plant (campanualaceae)
(East Carolina University, 2013)
The presence of a cleistogamous (obligately selfing) plant breeding system may have implications for reproductive isolation between species. The effects of this trait on plant hybridization previously have received little ...