Browsing Biomedical Sciences by Title
Now showing items 13-32 of 38
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Identification of Biomarkers in Non-Small Cell Lung Cancer Patients Treated with PD-1 Monoclonal Antibody Immunotherapy
(East Carolina University, 2018-08-22)Cancer immunotherapy works by taking a patient's existing immune system and priming it to recognize cancer cells in order for immune cells to mount an effective response to the disease. This is a less invasive means of ... -
Interrelated role of Notch signaling and mTORC pathways in prostate cancer cell survival and growth
(East Carolina University, 2014)Prostate cancer is currently the second highest leading cause of cancer death in men. Notch is a transmembrane receptor protein that is part of a signaling pathway necessary in the normal development of the prostate. ... -
Intratracheal instillation of silver nanoparticles exacerbates cardiac ischemia/reperfusion injury in male sprague-dawley rats
(East Carolina University, 2014)The uses of engineered nanomaterials have expanded in biomedical technology and consumer manufacturing. Exposure to particulate matter has been demonstrated to negatively influence cardiovascular health and expand myocardial ... -
Investigating the Role of Poxvirus Virulence Genes A35 and O1L in the Virus Life Cycle
(East Carolina University, 2019-07-22)Poxviruses, some of the largest viruses in existence, have a great impact on the human and animal world due to their ability to infect a broad assortment of organisms and cause significant disease. Today, poxvirus infections ... -
Kinin B1 Receptor Mediates Bidirectional Interaction between Neuroinflammation and Oxidative Stress
(East Carolina University, 2023-05-02)Hypertension is the leading risk factor for cardiovascular disease and affects nearly half the adults in the United States. It is well established that hypertension is a low-grade inflammatory condition and is associated ... -
Macrophage Regulation in the Murine Inflammatory Response
(East Carolina University, 2018-08-30)The development of acute and chronic liver disease is a complex condition involving the dysregulation of hepatic metabolism and the accumulation of critical immune cells; specifically, the recruitment and activation of ... -
Matrix Metalloproteinase 12 is Critical for Granuloma Formation in the Murine Model of Granulomatous disease
(East Carolina University, 2019-08-16)Matrix Metalloproteinase 12 (MMP12) is a protein produced primarily by alveolar macrophages that degrades elastin in the extracellular matrix (ECM) and enables infiltration of immune cells that participate in the inflammatory ... -
Method for nerve growth induction
(1993-03-16)A composition comprising nerve growth factor and 2-amino-1,1,3-tricyano-1-propene useful for the induction, stimulation, and maintenance of nerve growth, and methods of potentiating choline O-acetyltransferase and tyrosine ... -
Notch 3 Affects Chemoresistance in Colorectal Cancer via DNA Base Excision Repair Enzymes
(East Carolina University, 2017-07-28)Approximately 1.2 million cases of colorectal cancer (CRC) arise each year, and 40-50% of CRC patients will reach metastasis. The Notch pathway is known to be dysregulated in CRC, and its relationship with DNA repair ... -
Notch Signaling Mediates Drug Resistance in Colorectal Cancer Cells via Effects on DNA Repair Proteins
(East Carolina University, 2016-07-25)Colorectal cancer (CRC) is the second leading cause of cancer deaths in the United States and the third most commonly diagnosed cancer in men and women. Despite tremendous progress in diagnosis, prevention, and treatment ... -
Novel Function of PUF Proteins and Their Partners in Spermatogenesis and Spermatocyte-Derived Germline Tumors in Caenorhabditis elegans
(East Carolina University, 2022-04-27)Conserved PUF (Pumilio and FBF) proteins repress the translation by binding to its target mRNA 3' untranslated region (3'UTR). C. elegans has 11 PUF proteins. Among them, we focused on two FBFs (FBF-1 and FBF-2) and PUF-8. ... -
Peroxisome Proliferator-Activated Receptor Gamma Deficiency Promotes a T Lymphocyte Response in a Murine Model of Chronic Pulmonary Sarcoidosis
(East Carolina University, 2019-07-03)Sarcoidosis is a chronic granulomatous disease of unknown etiology. Previous studies from our lab have shown a deficiency of the nuclear transcription factor peroxisome proliferator-activated receptor gamma (PPAR[gamma]) ... -
Proposed regulatory role of noncatalytic Adams in ectodomain shedding
(East Carolina University, 2015)Members of the ADAM (A Disintegrin And Metalloprotease) protein family uniquely exhibit both proteolytic and adhesive properties. Specifically, ADAMs catalyze the conversion of cell-surface proteins to soluble, biologically ... -
PUF-8 and MPK-1: Genetic and Chemical Control of Spermatocyte Dedifferentiation in Caenorhabditis elegans
(East Carolina University, 2021-05-03)Stem cells face a number of major fate decision during their development: the decision to self-renew or differentiate, and then whether to remain differentiated or dedifferentiate, as occurs in some oncogenesis. A regulatory ... -
Pulmonary Pathologies Following Inhalation of Multi-Walled Carbon Nanotubes at Occupational Levels
(East Carolina University, 1/13/16)Multi-walled carbon nanotubes (MWCNT) are a nanomaterial that is growing in use and popularity. The health effects of occupational pulmonary exposure to MWCNT are currently unknown. The goals of this study were to build a ... -
Role of Notch signaling in tumorigenesis, stemness, and epithelial to mesenchymal transtion in colorectal cancer.
(East Carolina University, 2015)Colorectal cancer is the third most commonly diagnosed cancer in both men and women in the United States. Surgical resection and combination chemotherapy are often used for treatment, but in later stages of the disease, ... -
SPINAL CORD REFLEXES IN A BRAIN-IRON DEFICIENT MODEL OF RESTLESS LEGS SYNDROME: ROLE OF DOPAMINE AND ADENOSINE RECEPTORS
(East Carolina University, 2021-05-04)Restless Legs Syndrome (RLS) is a sensorimotor disorder that severely disrupts sleep. RLS patients regularly present with a condition known as Brain Iron Deficiency (BID), and BID is commonly associated with altered dopamine ... -
Structural and functional analysis of the Vaccinia virus O1 virulence protein
(East Carolina University, 2017-07-26)Poxviruses are double-stranded DNA viruses capable of causing disfiguring and deadly disease in a wide range of hosts, from insects to mammals. Orthopoxviruses (OPXV) encode many proteins that are not essential for viral ... -
Targeting Kremen1 Downregulation with RVG-9R/siRNA Complexes in the Triple-Transgenic Mouse Model of Alzheimer’s Disease
(East Carolina University, 2017-07-19)Alzheimer's disease (AD) is a progressive disease characterized by cognitive decline and memory loss. Memory loss observed in AD results from the loss of neurons and synapses which may be caused by the disruption of the ... -
TGF-β Signaling, Via Smad3, Mediates Notch Pathway-Induced Stemness and Epithelial to Mesenchymal Transition in Colon Cancer Cells
(East Carolina University, 2017-08-21)Late stage colorectal cancer (CRC) remains a challenging disease to treat due to several factors including stemness and epithelial to mesenchymal transition (EMT). Dysfunctional signaling pathways in CRC contribute to these ...