Pharmaceutically acceptable fixed-dried human blood platelets
Read, Marjorie S.; Reddick, Robert L.; Bode, Arthur P.
Fixed-dried human blood platelets and processes for preparing the same are disclosed. The platelets, upon reconstitution; adhere to thrombogenic surfaces; do not adhere to non-thrombogenic surfaces; undergo shape change (spreading) upon adhering to a thrombogenic surface; adhere to one another to form a hemostatic plug upon adhering to a thrombogenic surface; and release their granular contents. Pharmaceutical formulations containing the same are also disclosed. The platelets are preferably fixed by means of a fixative such as formaldehyde, paraformaldehyde, or glutaraldehyde, or fixed by means of a permanganate fixate. The platelets are preferably dried by lyophilization.