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Effects of 5-fluorouracil Drug Treatment on the Expression Profile of MicroRNAs in MCF7 Breast Cancer Cells
(East Carolina University, 2010)
Breast cancer is one of the leading causes of deaths in women worldwide. 5-flourouracil (5-FU) is a classic chemotherapeutic drug that has been widely used in the treatment of breast cancer patients. In this study, using ...
Coevolutionary analysis of Appalachian Xystodesmid millipedes and their symbiotic Mesostigmatid mites
(East Carolina University, 2010)
Mites (Acari) form symbiotic relationships with many animal taxa including fish, amphibians, reptiles, birds, mammals, mollusks, and arthropods. They are frequently found living on millipedes, and it has often been ...
Pleistocene glacial refugia across the Appalachian Mountains and coastal plain in the millipede genus Narceus: Evidence from population genetic, phylogeographic, and paleoclimatic data
(East Carolina University, 2009-01-30)
Background: Species that are widespread throughout historically glaciated and currently nonglaciated areas provide excellent opportunities to investigate the role of Pleistocene climatic change on the distribution of North ...
Functional Unit of the RNA Polymerase II C-Terminal Domain Lies within Heptapeptide PairsÂ
(East Carolina University, 2004-06)
Unlike all other RNA polymerases, the largest subunit (RPB1) of eukaryotic DNA-dependent RNA polymerase II (RNAP II) has a C-terminal domain (CTD) comprising tandemly repeated heptapeptides with the consensus sequence ...
THE COROLLA WRECK EXPOSED : HISTORICAL ARCHAEOLOGICAL ANALYSIS OF NORTH CAROLINA'S OLDEST SHIP
(East Carolina University, 2013)
Because of the unexpected and spontaneous discovery of the Corolla Wreck in 2008, its relocation in 2009, and its dynamic six-month jaunt up and down the coast, all research questions posed by this thesis were formed in ...
Defining Eastern North Carolina Upriver Steamboats Through Tar River Archaeology and History
(East Carolina University, 2012)
This thesis will identify the salient features of North Carolina upriver steamboats and their relationships to steamboats from a variety of regions in the United States in an effort to understand the means by which people ...
Consequences of Reduced Versican Expression in Embryonic Chick Synovial Joint Development
(East Carolina University, 2012)
The different mechanisms involved in vertebrate synovial joint development are actively being uncovered. A variety of studies have thus far discovered the involvement of several large molecules in the processes of joint ...
Multiple Factors Influence the Strength of Intraguild Interactions
(East Carolina University, 2011)
Species engaged in intraguild predation (IGP) not only compete for the same food resources but can also eat each other. In some cases, a predator species in a higher trophic position (i.e., a top predator) can eat a ...
Analyses of domains and domain fusions in human proto-oncogenes
(East Carolina University, 2009-03-17)
Background: Understanding the constituent domains of oncogenes, their origins and their fusions may shed new light about the initiation and the development of cancers. Results: We have developed a computational pipeline ...
Ancient Genome Duplications Did Not Structure the Human Hox-Bearing Chromosomes
(East Carolina University, 2001-05)
The fact that there are four homeobox (Hox) clusters in most vertebrates but only one in invertebrates is often cited as evidence for the hypothesis that two rounds of genome duplication by polyploidization occurred early ...