Browsing Biology by Type"Honors Thesis"
Now showing items 21-40 of 62
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Folic acid elicits diverse effects over all major life stages and body systems
(East Carolina University, 2018-04-25)Over several decades, the vitamin supplement folic acid has been praised for its ability to reduce neural tube defects in the developing embryo. Many studies show that folic acid plays a vital role in the reduction of ... -
A Genetic Screen for Mcm10: Interactions Between Mcm10 and Deficiency Regions on the Third Chromosome of Drosophila Melanogaster
(2015)Mis-regulation of the Mcm10 gene has been linked with multiple forms of cancer, including many forms of breast cancer (Thu, Y. 2014). Despite this, the role of Mcm10 in cancer is not yet fully known. One way to study a ... -
Genomic Database Conundrum: Widespread Misannotation of rRNA Sequences as Protein Sequences
(East Carolina University, 2017-12-11)The genomics revolution introduced affordable technology capable of rapidly analyzing and comparing massive amounts of biological sequence data. Using the Basic Local Alignment Search Tool (BLAST) program on the National ... -
Hormone Exposure During Pregnancy and Maternal Care
(East Carolina University, 2015-12-17)It is suspected that prenatal hormones can affect maternal care, which has important implications for the neurological development of pups. To determine if the altered hormone levels affected maternal care, pregnant dams ... -
HUMAN T-CELL LEUKEMIA VIRUS TYPE 1-ENCODED PROTEIN HBZ INCREASES VIRAL INFECTION
(East Carolina University, 2017-05-04)Human T-lymphotropic virus type 1 (HTLV-1) is a complex retrovirus, infecting CD4+ T lymphocytes. About 10 million people worldwide are infected with HTLV-1. HTLV-1 has been linked to adult T-cell leukemia (ATL), a disease ... -
Implementing a high sensitivity point-of-care troponin assay is beneficial in an emergency department chest pain population
(East Carolina University, 2017-05-03)Point of care tests (POC) can provide accurate and more rapid results for physicians at the bedside, thus decreasing the patient’s time to treatment and increasing patient prognosis. Cardiac troponin (cTnI) is the leading ... -
INTERACTION BETWEEN HTLV-1 BASIC LEUCINE ZIPPER FACTOR (HBZ) AND HOST CELL PROTEINS PROMOTES CELLULAR TRANSFORMATION
(2016-04-26)Human T-cell Leukemia Virus Type 1 (HTLV-1) is a complex retrovirus which preferentially infects CD4+ T-cells. Endemic to Japan, regions of South America, Africa, and the Caribbean, HTLV-1 is transmitted through breastfeeding, ... -
Investigating the Impact of Mettl16 Cellular Localization on RNA Binding Preferences
(East Carolina University, 2019-05-14)Recently, mRNA modification by N6-methyladenosine (m6A) has been shown to be involved in post-transcriptional regulation processes including mRNA stability, splicing and promotion of translation. Accordingly, the mRNA ... -
INVESTIGATING THE MOLECULAR CONTROL OF ECDYSONE RESPONSE GENE, E74, IN THE DROSOPHILA OVARY.
(East Carolina University, 2017-05-05)Oogenesis is the process by which an egg develops from precursor cells in the ovary. This process has been widely studied; however, many of the molecular mechanisms that regulate oocyte development and growth remain unclear. ... -
Investigating the Role of CtBP in Colorectal Cancer
(2015-04-29)Recent studies in breast cancer tissue have demonstrated that C-terminal binding protein (CtBP) over-expression induces stem cell-like features and genome instability; whereas CtBP depletion or caloric restriction reverses ... -
KNOWLEDGE AND PERCEPTION OF TYPE 2 DIABETES PREVALENCE AND TREATMENT AMONG STUDENTS AT EAST CAROLINA UNIVERSITY
(East Carolina University, 2019-05-03)The present study will investigate the basic understanding of type 2 diabetes treatment and prevalence among college students in Eastern North Carolina. The data gathered could promote programs that more effectively educate ... -
Macronutrient Intake of Pregnant Exercisers and Non-Exercisers
(East Carolina University, 2016-04-28)With the childhood obesity pandemic, it is vital for pregnant women to focus on healthy habits (i.e. proper nutrition, exercise) in order to ensure a positive in utero environment. Exercise during pregnancy is associated ... -
MCM10 Genetic Screen Using Drosophila melanogaster
(East Carolina University, 2016-04-28)Genes and the proteins they encode are responsible for virtually every aspect of life. The vast array of biological processes make it difficult to identify genes to study that are relevant to human diseases. MCM10 (short ... -
Microsatellite analysis of brook trout, Salvelinus fontinalis, in western Pennsylvania
(East Carolina University, 2017-05-05)In western Pennsylvania, the brook trout, Salvelinus fontinalis, has dramatically declined in population due to the environmental stressors of mining, logging, water withdrawal, and acid deposition. Brook trout are game ... -
MITOCHONDRIAL DNA VARIATION IN THE PITCHER PLANT FLY SARCOPHAGA SARRACENIAE: EXPLORING POSSIBLE INFLUENCES OF HOST SPECIFICITY AND GEOGRAPHIC STRUCTURING
(East Carolina University, 2019-05-03)North American pitcher plants (Sarracenia) are a recently evolved (~3 my) assemblage of 11 carnivorous species. Sarracenia pitchers also provide resources (food, shelter) for certain arthropods, including two genera of ... -
Molecular chaperone Tetratricopeptide repeat protein 2 (Tpr2) is essential for germline stem cell self-renewal and timely cyst divisions in Drosophila melanogaster oogenesis
(East Carolina University, 2019-05-02)Steroid hormones influence cell proliferation and cell fate in developing and injured tissues. Although steroid hormone signaling has been well-studied, the precise mechanisms by which cells specifically receive steroid ... -
Nicotine Controlof Germline Cell Fate in Caenorhabditis elegans
(2015-05)Nicotine dependence is the single largest cause of preventable death in the world, claiming 480,000 lives each year in the US alone, including those caused by secondhand smoke. In this study, we investigated the biological ... -
OPTIMIZATION OF AN OPTOGENETICALLY ACTIVATED INITIATOR OF APOPTOSIS
(East Carolina University, 2018-05-03)Optogenetic tools provide a window into the world of cell signaling pathways and protein-protein interactions with a precision and elegance that other biological probes can struggle to achieve. The creation of optogenetic ... -
Prevention of synaptic loss in cortico-hippocampal culture by silencing Kremen1 with siRNA
(East Carolina University, 2017-05-19)Research has shown that Alzheimer’s disease could be a result of an accumulation of amyloid β (Aβ) plaques and tau protein. The accumulation of Aβ activates p53, which leads to an increase of Dickkopf-1 (Dkk1). When Dkk1 ... -
Purifying Scorpion Antarease from E. coli
(East Carolina University, 2018-05-03)Vesicular trafficking is a system of intracellular transport that allows for the distribution and secretion of molecules. In the pancreas, normal secretory processes have been found to be interrupted by Antarease, a ...