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Connecting Mutations of the RNA Polymerase II C-Terminal Domain to Complex Phenotypic Changes Using Combined Gene Expression and Network Analyses
(2010)
The C-terminal domain (CTD) of the largest subunit in DNA-dependent RNA polymerase II (RNAP II) is essential for mRNA synthesis and processing, through coordination of an astounding array of protein-protein interactions. ...
Duodenal carcinoma at the ligament of Treitz. A molecular and clinical perspective
(2010)
Background
There is very small occurrence of adenocarcinoma in the small bowel. We present a case of primary duodenal adenocarcinoma and discuss the findings of the case diagnostic modalities, current knowledge on the ...
Acute effects of fine particulate air pollution on ST segment height: A longitudinal study
(2010)
Background
The mechanisms for the relationship between particulate air pollution and cardiac disease are not fully understood. Air pollution-induced myocardial ischemia is one of the potentially important mechanisms.
...
Phylogeny and Classification of the Trapdoor Spider Genus : An Integrative Approach to Evaluating Taxonomic Hypotheses
(2010)
Background
Revised by Bond and Platnick in 2007, the trapdoor spider genus Myrmekiaphila comprises 11 species. Species delimitation and placement within one of three species groups was based on modifications of the male ...
Deep sequencing identifies novel and conserved microRNAs in peanuts (L.)
(2010)
Background
MicroRNAs (miRNAs) are a new class of small, endogenous RNAs that play a regulatory role in the cell by negatively affecting gene expression at the post-transcriptional level. miRNAs have been shown to control ...
Predator Out of Place : The Differential Impacts of Native and Non-native Crayfish on Bufo Tadpoles
(East Carolina University, 2010)
Predators have been shown to alter important fitness components (larval period, mass at metamorphosis, and overall survivorship) of larval anurans. Uncommonly studied predators of tadpoles include crayfish. Both native and ...
DEHP Impairs Zebrafish Reproduction by Affecting Critical Factors in Oogenesis
(East Carolina University, 2010-04-15)
Public concerns on phthalates distributions in the environment have been increasing since they can cause liver cancer, structural abnormalities and reduce sperm counts in male reproductive system. However, few data are ...
Effects of 5-fluorouracil Drug Treatment on the Expression Profile of MicroRNAs in MCF7 Breast Cancer Cells
(East Carolina University, 2010)
Breast cancer is one of the leading causes of deaths in women worldwide. 5-flourouracil (5-FU) is a classic chemotherapeutic drug that has been widely used in the treatment of breast cancer patients. In this study, using ...
Coevolutionary analysis of Appalachian Xystodesmid millipedes and their symbiotic Mesostigmatid mites
(East Carolina University, 2010)
Mites (Acari) form symbiotic relationships with many animal taxa including fish, amphibians, reptiles, birds, mammals, mollusks, and arthropods. They are frequently found living on millipedes, and it has often been ...
Tumor Growth Induces Oxidative Clustered DNA Lesions Damage in Distant Mouse Tissue in vivo
(East Carolina University, 2010)
Our goal was to ascertain if DNA damage induced by oxidative stress is capable of being exploited as a precancerous or cancer biomarker. The specific DNA damage that we assessed was oxidatively induced non-DSB clustered ...