Browsing Chemistry by Submit Date
Now showing items 41-60 of 101
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Quinone Formation via Ceric Ammonium Nitrate Oxidations of 2-Alkyl-1,4-dialkoxybenzenes
(East Carolina University, 2016-05-03)Quinones are cyclohexadiendiones that have a variety of uses ranging from medical applications to synthetic building blocks. Medicinal applications stem from the potent biological activity (e.g. antitumor and antibiotic) ... -
Tissue lockable connecting structures
(2006-08-01)Percutaneous skin access devices include a plurality of locked connecting units mounted to the exterior surface of an implantable medical object which, in position, is configured to penetrate the skin of a subject. The ... -
Wurster's crown ligands
(2001-07-17)Wurster's crown ligands comprise a macrocyclic ligand such as a crown ether in which a hetero atom is substituted with a 1,4-phenylenediamine group. The phenylenediamine group is covalently bound to the macrocyclic ligand ... -
Wurster's crown ligands
(2002-08-27)Wurster's crown ligands comprise a macrocyclic ligand such as a crown ether in which a hetero atom is substituted with a 1,4-phenylenediamine group. The phenylenediamine group is covalently bound to the macrocyclic ligand ... -
Biimidazole diamide anion binding agents
(2006-07-18)Biimidazole diamide compounds that are useful for binding anions such as sulfate are described, along with the use thereof for purposes such as extracting anions from a waste stream and/or detecting anions. -
Investigating Intra- and Inter-Molecular Coevolution of Intrinsically Disordered Protein, Prothymosin-alpha
(East Carolina University, 1/13/16)Prothymosin-α (ProTα) is a small, highly acidic protein found in the nuclei of virtually all mammalian tissues. It belongs to a class of proteins known for their lack of a rigid three-dimensional structure called intrinsically ... -
Investigation Into The Scope, Limitations, And Mechanistic Aspects Of A Regioselective Acylation Of Cycloplatinated Complexes
(East Carolina University, 2015)In the reaction of N-isopropyl-N-phenyl-2,2'-bipyridin-6-amine with potassium tetrachloroplatinate, the selective C-H bond activation was complicated by the low selectivity of sp² C-H bond activation in acetonitrile and ... -
Thermodynamic and spectroscopic studies of Cd²⁺ binding to the regulatory domain and full length human cardiac troponin C (HcTnC) : elucidating plausible Cd²⁺ binding sites
(East Carolina University, 2015)Toxic metals such as cadmium (Cd²⁺) have been shown to bind to and interfere with various calcium (Ca²⁺) binding proteins including the regulatory protein cardiac troponin C (cTnC). Recent structural data has shown that ... -
Synthesis Of Non-Natural Fmoc-Protected Amino Acids To Provide Novel Fluorescent Anion Probes And Their Incorporation Into Synthetic Peptides
(East Carolina University, 2015)Cystic fibrosis is a genetic disorder caused by mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) protein. CFTR serves to control the gradient of chloride and bicarbonate ions across the cellular ... -
Electrochemical Detection of Anti-Biofilm Activity Using Unnatural Amino Acid-Containing Antimicrobial Peptides
(East Carolina University, 2015)Bacterial infections are a significant health problem that can be detrimental to the human population. It is estimated that bacterial infections are responsible for billions of dollars’ worth of damages in the health care ... -
Molecular Dynamics Studies of Point Mutations of Cardiac Troponin C and Annexin
(East Carolina University, 2015)Calcium binding proteins are biologically important for their ability to convert changes in calcium ion concentration to functional changes in proteins. All calcium binding proteins use a calcium sensing motif that changes ... -
A Calorimetric and Spectroscopic Study of the Interactions Between Model Lipid Membrane Bilayers and Simple Sugars
(East Carolina University, 2015)It is well known that various organisms, such as the tardigrade, naturally use carbohydrates, particularly disaccharides, to help preserve their cell structural and functional integrity during freezing or dehydration. There ... -
Conservation of Archaeological Wood using Non-Reducing sugars
(2015)In the conservation field there are many different thoughts on the best way to conserve waterlogged archaeological wood. The current method uses polyethylene glycol(PEG), a hydrophilic organic compound, to replace water ... -
Installation of Metal-Binding Functionality at Lysine Residues via Azide-Alkyne "Click Chemistry"
(2015-04-29)A novel non-natural amino acid designed to bind divalent metal ions, dubbed Lys(PYRIT), was prepared in a “click reaction” by treating Fmoc-Lys(N3)-OH with 2-ethynylpyridine and Cu(I). It was incorporated into a 12-residue ... -
Recognition of bacterial lipid headgroups by fluorescent crown ether-naphthalimides
(2015)The increasing incidence of antibiotic- resistant bacterial strains is a significant threat to human health. New antimicrobial mechanisms that feature reduced resistance potential are necessary to slow down the rapid ... -
Identification of Damaged DNA Adducts from Exposure to Benzo[a]pyrene in the TP53 Gene
(2015)Benzo[a]pyrene is a carcinogen associated with tobacco smoke that can damage DNA after it is metabolized into highly reactive forms. Identifying the resulting DNA adducts can give greater insight into the mutations that ... -
Fundamental and Applied Studies on Chromatographic Separation of Cold Drugs and Skincare Creams and Extraction of Salvia miltiorrhiza using Subcritical Water
(East Carolina University, 2014)Subcritical water chromatography (SBWC) and subcritical water extraction (SBWE) are two green techniques that use subcritical water as the sole solvent for separations, thus eliminating the use of toxic and expensive organic ... -
Investigation of the Zinc binding region of Prothymosin-alpha : A spectroscopic and thermodynamic approach to study metal binding in Intrinsically disordered proteins
(East Carolina University, 2014)The goal of this study is to provide a deeper insight into how metals bind intrinsically disordered proteins (IDPs) by taking zinc binding to prothymosin-alpha as a case study. The involvement of metals in several diseases ...