Browsing Chemistry by Submit Date
Now showing items 1-20 of 120
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A Catalytic Approach to Cyclopentenones: Unexpected Challenges in Synthesizing Pent-2,4-dienals
(East Carolina University, 2023-05-04)Transition metal catalysis has long been utilized to facilitate a number of chemical reactions outside the scope of traditional organic chemistry. Because of this, there has been a growing interest in the community in ... -
Towards Establishing Methods of Synthesis, Purification, and Structural Determination for Human Fibrinogen
(East Carolina University, 2023-05-04)Fibrinogen is a prevalent blood-based glycoprotein. In its polymerizable form, fibrin, it serves as the structural component of blood clots and helps to incorporate red blood cells, macrophages, and fibroblasts to the ... -
Improving Prostamide Anti-Cancer Activity Through Derivatization and Micellar Delivery
(East Carolina University, 2023-04-28)Colorectal cancer is the fourth most common cancer diagnosis per year as well as the fourth highest rate of death per year according to the Centers for Disease Control. Approximately 1/3rd of the diagnosed colorectal cancer ... -
Red Blood Cell Preservation Under Austere Conditions
(East Carolina University, 2023-01-05)In the United States, the maximum approved preservation time for red blood cells under hypothermic storage conditions is 42 days when treated with an appropriate additive solution, namely AS-1. In this investigation, we ... -
Binding of Calcium and Magnesium to Human Cardiac Troponin C
(2021-02-03) -
Subcritical Water Extraction of Salvia miltiorrhiza
(2021-03-15) -
Investigation of Molecular Mechanism of Transthyretin Oligomerization Associated with ATTR Amyloidosis
(East Carolina University, 2022-04-27)Transthyretin amyloidosis (ATTR) has classically been diagnosed predominantly post-observation of amyloid fibril deposition on soft tissues within the body, however, recent studies have shown that oligomers which arise ... -
Biophysical Investigation into the Protein Dynamics Governing the Allosteric Regulation of Plant and Animal 15-Lipoxygenases
(East Carolina University, 2022-04-27)Lipoxygenases (LOXs) are a family of enzymes found in plants, animals, fungi, and bacteria that catalyze the per-oxidation of polyunsaturated fatty acids. In plants, LOXs are involved in growth, development, and defense ... -
Defining Protein Motions the Comprise the Reaction Barrier in Human Epithelial 15-Lipoxygenase-2
(East Carolina University, 2022-04-27)Proteins are dynamic in nature, with these motions playing a role in substrate binding and product release. Protein thermal motions have emerged as participating in the bond making/breaking steps of catalysis and by extension ... -
A Carbohydrate/Lipid Research Project for Organic and Analytical CURE Laboratories: Reactions and Recordkeeping
(East Carolina University, 2021-05-06)Course-based Undergraduate Research Experiences (or CUREs) are able to teach students laboratory skills while engaging them in novel research. The first part of this thesis aims to demonstrate the development of a feasible ...