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Thermodynamic Investigations into Copper Binding in the N-Terminal Region of the Prion Protein at Low Copper Loadings
(East Carolina University, 2010)
The prion protein (PrP) is a naturally occurring protein found at high levels in central nervous system (CNS). The misfolding of the PrP is responsible for neurodegenerative diseases called transmissible spongioform ...
Thermodynamic Investigation of Copper Binding to the Amyloid-Beta (A[beta]) Peptide
(East Carolina University, 2010)
Alzheimer's disease is a fatal and neurodegenerative disease with as many as 5.3 million Americans living with the disease. One of the characteristic hallmarks of Alzheimer's is the amyloid plaques that build up around the ...
A Molecular Dynamics Study into Annexin A1 Induced Membrane Binding and Aggregation
(East Carolina University, 2010)
Annexins constitute a family of proteins that bind to anionic membranes in a reversible and calcium dependent manner through the unique architecture of their calcium binding sites. In addition, annexins with relatively ...
Thermodynamic Investigation into the Binding Properties of Cardiac Troponin (Human and Bovine)
(East Carolina University, 2010)
Troponin is an integral protein in the mechanism of muscle contraction. In order to induce cardiac muscle contraction, Ca[superscript]2[superscript]+ must bind to the TnC subunit (calcium binding subunit) of troponin to ...
Prothymosin-Alpha : Features of the protein sequence that contribute to the anti-HIV Activity
(East Carolina University, 2010)
Prothymosin-alpha (ProT[alpha]) is a protein mainly located in the nucleus of the cells. Though its exact function is not known, it is believed to be involved in cell proliferation. The ability of this protein to inhibit ...
Surfactant Assisted Electrospray Ionization Time of Flight Mass Spectrometry of Synthetic Polymers
(East Carolina University, 2010)
Synthetic polymers are complex mixtures which often require extensive characterization to determine chemical composition and structure. Mass spectrometric techniques have greatly enhanced the quantity, as well as the ...
WATER-SOLUBLE FLUORESCENT PH SENSORS BASED ON A DIARYLACETYLENE SCAFFOLD
(East Carolina University, 2010)
Intracellular pH plays an important role in many biological processes: receptor-mediated signal transduction, enzymatic activity, cell growth and death, ion transport and homeostasis, calcium regulation, endocytosis, ...
Solvent-Controlled Switch of Selectivity between sp[superscript]2 and s[superscript]p3 C-H Bond Activation by Platinum (II)
(East Carolina University, 2010)
Cyclometalation reactions have been studied intensely for the past few decades, especially those containing palladium. The factors that control the process of the C-H bond activation, however, are not yet completely ...