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Studying Collagen with PyrATS: Pyrene-Appended Trimeric Systems
(East Carolina University, 2019-07-30)
Collagens are a family of triple-helical structural proteins that are ubiquitous in vertebrates. Improper folding of collagen can lead to disorders such as osteogenesis imperfecta, or "brittle bone disease." There is ...
EXPLORATION INTO THE SCOPE AND MECHANISM OF THE PLATINUM-CATALYZED ACYLATION OF 2-(ARYLOXY)PYRIDINES
(East Carolina University, 2019-07-11)
Transition metal catalysts have played a key role in direct C-H bond functionalization. However, one main drawback of these reactions is that oxidants and additives are often required to regenerate the active catalyst, ...
Computational Investigation of Calcium Binding Proteins Annexin A1 and Cardiac Troponin C
(East Carolina University, 2019-07-15)
Calcium binding proteins are vital for many biological functions. Many undergo calcium induced conformation changes through sensing motifs, resulting in functional changes for the proteins. In this study computational ...
THE IMPACT OF GLYCOSYLATION ON ACTIVE SITE STRUCTURE AND ACTIVITY IN THE FUNGUS ENZYME MOLOX
(East Carolina University, 2019-05-01)
Lipoxygenases from pathogenic fungi belong to the lipoxygenase family that catalyze the C-H activation of polyunsaturated fatty acids to form diverse hydroperoxides. While the lipoxygenase catalytic domains are structurally ...
Benzoate: The Quantitation of Soft Drinks Implicated in Obesity
(East Carolina University, 2019-04-26)
Research has shown that childhood obesity is a leading cause of diseases such as coronary artery disease, hypertension, type 2 diabetes, cancer, osteoarthritis, and many more. With approximately 17 percent of the United ...
Platinum Catalyzed Synthesis of Alpha-Ketoester via C-H Functionalization
(East Carolina University, 2019-12-16)
Alpha-ketoesters have proven to be useful in a variety of fields. They have found wide spread applications in pharmaceuticals, photochemistry, and biology. Additionally, they are of great interest in synthetic chemistry ...
Development of Green Subcritical Water Separation Technology
(East Carolina University, 2019-08-19)
Theoretically speaking, water under temperature and pressure conditions below its critical point is called subcritical water. However, the term “subcritical water” normally refers to hot water up to 374 C and pressure up ...
Theoretical Probe to the Mechanism of Pt-catalyzed C-H Acylation Reaction: Possible Pathways for the Key Acylation Reaction of Platinacycles
(East Carolina University, 2019-08-23)
Transition metal-catalyzed C-H bond functionalization offers a variety of desirable transformations of simple hydrocarbons to more complex compounds with applications being applied in pharmaceuticals to material sciences. ...