Now showing items 1042-1061 of 1351

  • Quality Improvement Initiative to Improve Weight Management in Primary Care 

    Jackson, Kimberly (2017-04-17)
    A Quality Improvement Initiative to Improve Weight Management in Primary Care Obesity has become a major health problem. The disease and its associated comorbidities impact health of patients and increase healthcare ...
  • Quality of life and BMI changes in youth participating in an integrated pediatric obesity treatment program 

    Pratt, Keeley J.; Lazorick, Suzanne; Lamson, Angela L.; Ivanescu, Andrada; Collier, David N. (2013)
    Background Changes in Quality of Life (QOL) measures over time with treatment of obesity have not previously been described for youth. We describe the changes from baseline through two follow up visits in youth QOL (assessed ...
  • QUANTITATION OF INTERCELLULAR CONNECTIONS BETWEEN SPERMATOGONIA IN THE MOUSE 

    Cook, Kenneth (East Carolina University, 2017-05-09)
    Spermatogonial stem cells (SSCs) are critical in the male reproductive process, as they can either self-renew or proliferate into progenitor cells that differentiate to enter meiosis and eventually form functional sperm. ...
  • Quantitative phosphoproteome analysis of embryonic stem cell differentiation toward blood 

    Piazzi, Manuela; Williamson, Andrew; Lee, Chia-Fang; Pearson, Stella; Lacaud, Georges; Kouskoff, Valerie; McCubrey, James A.; Cocco, Lucio; Whetton, Anthony D. (2015-05)
    Murine embryonic stem (ES) cells can differentiate in vitro into three germ layers (endodermic, mesodermic, ectodermic). Studies on the differentiation of these cells to specific early differentiation stages has been aided ...
  • A Quantitative Survey of Gravity Receptor Function in Mutant Mouse Strains 

    Jones, Sherri M.; Johnson, Kenneth R.; Yu, Heping; Erway, Lawrence C.; Alagramam, Kumar N.; Pollak, Natasha; Jones, Timothy A. (East Carolina University, 2005-12)
    The purpose of this research was to identify vestibular deficits in mice using linear vestibular evoked potentials (VsEPs). VsEP thresholds, peak latencies, and peak amplitudes from 24 strains with known genetic mutations ...
  • Quantum dot labeling of mesenchymal stem cells 

    Muller-Borer, Barbara J.; Collins, Maria C.; Gunst, Philip R.; Cascio, Wayne E.; Kypson, Alan P. (East Carolina University, 2007-11-07)
    Background: Mesenchymal stem cells (MSCs) are multipotent cells with the potential to differentiate into bone, cartilage, fat and muscle cells and are being investigated for their utility in cell-based transplantation ...
  • Quinolone signaling in the cell-to-cell communication system of Pseudomonas aeruginosa 

    Pesci, Everett C.; Milbank, Jared B. J.; Pearson, James P.; McKnight, Susan L.; Kende, Andrew S.; Greenberg, E. Peter; Iglewski, Barbara H. (East Carolina University, 1999-09-28)
    Numerous species of bacteria use an elegant regulatory mechanism known as quorum sensing to control the expression of specific genes in a cell-density dependent manner. In Gram-negative bacteria, quorum sensing ...
  • Race, insurance type, and stage of presentation among lung cancer patients 

    Efird, Jimmy T.; Landrine, Hope; Shiue, Kristin Y.; O'Neal, Wesley T.; Podder, Tarun; Rosenman, Julian G.; Biswas, Tithi (2014-12)
  • Racial difference in Acylation Stimulating Protein (ASP) correlates to triglyceride in non-obese and obese African American and Caucasian women 

    Scantlebury-Manning, Thea; Bower, Joseph F.; Cianflone, Katherine; Barakat, Hisham A. (East Carolina University, 2009-04-17)
    Background: Acylation Stimulating Protein (ASP) has been shown to influence adipose tissue triglyceride (TG) storage. The aim was to examine ethnic differences in ASP and leptin levels in relation to lipid profiles and ...
  • Racial Differences in Survival among Hemodialysis Patients after Coronary Artery Bypass Grafting 

    Efird, Jimmy T.; O'Neal, Wesley T.; Bolin, Paul; Davies, Stephen W.; O'Neal, Jason B.; Anderson, Curtis A.; Ferguson, T. Bruce; Chitwood, W. Randolph; Kypson, Alan P. (2013-09)
    The aim of this study was to examine racial differences in long-term survival among hemodialysis patients after coronary artery bypass grafting (CABG). To our knowledge this has not been previously addressed in the literature. ...
  • Radiation isocenter measurement devices and methods and 3-D radiation isocenter visualization systems and related methods 

    Jenkins, Todd; Allison, Ron R.; Sibata, Claudio (2008-05-25)
    A three-dimensional phantom assembly for use with a radiation treatment device includes a three-dimensional support member having at least two, spaced apart opposed surfaces configured to hold at least one generally planar ...
  • Radioprotective Effect of American Ginseng on Human Lymphocytes at 90 Minutes Post-irradiation: A Study of 40 Cases 

    Lee, Tung-Kwang; O'Brien, Kevin F.; Wang, Weidong; Johnke, Roberta M.; Sheng, Chao; Benhabib, Sidi Mohammed; Wang, Tao; Allison, Ron R. (East Carolina University, 2010-05)
    Backgroundâ Ionizing radiation (IR) initiates intracellular oxidative stress through enhanced formation of reactive oxygen species (ROS) that attack DNA leading to cell death. As the diversity of IR applied in medicine, ...
  • Raf-Induced Vascular Endothelial Growth Factor Augments Kaposi's Sarcoma-Associated Herpesvirus Infection 

    Hamden, Khalief E.; Ford, Patrick W.; Whitman, Audy G.; Dyson, Ossie F.; Cheng, Shi-Yuan; McCubrey, James A.; Akula, Shaw M. (East Carolina University, 2004-12)
    Recombinant green fluorescent protein encoding Kaposi’s sarcoma-associated herpesvirus (rKSHV.152) infection of -estradiol stimulated human foreskin fibroblasts (HFF) or HFF/ B-Raf[FF]:ER (expressing a weaker form of ...
  • Raman spectroscopy: the gateway into tomorrow's virology 

    Lambert, Phelps J.; Whitman, Audy G.; Dyson, Ossie F.; Akula, Shaw M. (East Carolina University, 2006-06-28)
    In the molecular world, researchers act as detectives working hard to unravel the mysteries surrounding cells. One of the researchers' greatest tools in this endeavor has been Raman spectroscopy. Raman spectroscopy is a ...
  • Raman tweezers provide the fingerprint of cells supporting the late stages of KSHV reactivation 

    Dyson, Ossie F.; Ford, Patrick W.; Chen, De; Li, Yong-Qing; Akula, Shaw M. (East Carolina University, 2009-08)
    Kaposi's sarcoma-associated herpesvirus (KSHV) has both latent and lytic phases of replication. The molecular switch that triggers a reactivation is still unclear. Cells from S phase of cell cycle provide apt conditions ...
  • Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascade Inhibitors: How Mutations Can Result in Therapy Resistance and How to Overcome Resistance 

    McCubrey, James A.; Steelman, Linda S.; Chappell, William H.; Abrams, Stephen L.; Franklin, Richard A.; Montalto, Giuseppe; Cervello, Melchiorre; Libra, Massimo; Candido, Saverio; Malaponte, Graziella; Mazzarino, Maria C.; Fagone, Paolo; Nicoletti, Ferdinando; Bäsecke, Jörg; Mijatovic, Sanja; Maksimovic-Ivanic, Danijela; Milella, Michele; Tafuri, Agostino; Chiarini, Francesca; Evangelisti, Camilla; Cocco, Lucio; Martelli, Alberto M. (2012-10)
    The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are often activated by genetic alterations in upstream signaling molecules such as receptor tyrosine kinases (RTK). Integral components of these pathways, Ras, B-Raf, ...
  • Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health 

    Chappell, William H.; Steelman, Linda S.; Long, Jacquelyn M.; Kempf, C. Ruth; Abrams, Stephen L.; Franklin, Richard A.; Bäsecke, Jörg; Stivala, Franca; Donia, Marco; Fagone, Paolo; Malaponte, Graziella; Mazzarino, Maria C.; Nicoletti, Ferdinando; Libra, Massimo; Maksimovic-Ivanic, Danijela; Mijatovic, Sanja; Montalto, Giuseppe; Cervello, Melchiorre; Laidler, Piotr; Milella, Michele; Tafuri, Agostino; Bonati, Antonio; Evangelisti, Camilla; Cocco, Lucio; Martelli, Alberto M.; McCubrey, James A. (2011-03)
    The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are often activated by genetic alterations in upstream signaling molecules such as receptor tyrosine kinases (RTK). Integral components of these pathways, Ras, B-Raf, ...
  • Rat-bite fever as a cause of septic arthritis: a diagnostic dilemma. 

    Rumley, Richard L.; Patrone, Nicholas A.; White, Lindsey (East Carolina University, 1987-10)
    Rat-bite fever results from an infection with the organism Streptobacillus moniliformis. Symptomatic patients often present with fever, malaise, cough, maculopapular rash, and occasional arthritis, and usually have a history ...
  • RecA and RadA Proteins of Brucella abortus Do Not Perform Overlapping Protective DNA Repair Functions following Oxidative Burst 

    Roux, Christelle M.; Booth, Natha J.; Bellaire, Bryan H.; Gee, Jason M.; Roop, R. Martin II; Kovach, Michael E.; Tsolis, Renee M.; Elzer, Philip H.; Ennis, Don G. (East Carolina University, 2006-07)
    Very little is known about the role of DNA repair networks in Brucella abortus and its role in pathogenesis. We investigated the roles of RecA protein, DNA repair, and SOS regulation in B. abortus. While recA mutants in ...
  • Recent discoveries in the cycling, growing and aging of the p53 field 

    McCubrey, James A.; Demidenko, Zoya N. (2012-12)
    The P53 gene and it product p53 protein is the most studied tumor suppressor, which was considered as oncogene for two decades until 1990. More than 60 thousand papers on the topic of p53 has been abstracted in Pubmed. ...