Browsing Health Sciences Campus by Author "Jones, Sherri M."
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Characterization of Vestibular Dysfunction in the Mouse Model for Usher Syndrome 1F
Alagramam, Kumar N.; Stahl, John S.; Jones, Sherri M.; Pawlowski, Karen S.; Wright, Charles G. (East Carolina University, 2005-06)The deaf-circling Ames waltzer (av) mouse harbors a mutation in the protocadherin 15 (Pcdh15) gene and is a model for inner ear defects associated with Usher syndrome type 1F. Earlier studies showed altered cochlear hair ... -
A comparison of vestibular and auditory phenotypes in inbred mouse strains
Jones, Sherri M.; Jones, Timothy A.; Johnson, Kenneth R.; Yu, Heping; Erway, Lawrence C.; Zheng, Qing Y. (East Carolina University, 2006-05-26)The purposes of this research were to quantify gravity receptor function in inbred mouse strains and compare vestibular and auditory function for strain- and age-matched animals. Vestibular evoked potentials (VsEPs) were ... -
Functional Aging of the Inner Ear Sensory Systems in Mouse Models of Age-Related Hearing Loss
Mock, Bruce Elliott (East Carolina University, 2009)Age related structural and functional change in the cochlea have been well described and predisposing factors including genetic background, gender, and environmental factors have been identified. To date, nine genetic loci ... -
Insights Into Elevated Distortion Product Otoacoustic Emissions In Sickle Cell Disease: Comparisons of Hydroxyurea-treated and Non-treated Young Children
Stuart, Andrew; Jones, Sherri M. (East Carolina University, 2006)Distortion product otoacoustic emissions (DPOAEs) were examined in 15 normal- hearing African-American children between the ages of 6 and 14 years with homozygous sickle cell disease (SCD), who were on a regimen of hydroxyurea ... -
Orphan Glutamate Receptor delta-1 Subunit Required for High-Frequency Hearing
Gao, Jiangang; Maison, Stephane F.; Wu, Xudong; Hirose, Keiko; Jones, Sherri M.; Bayazitov, Ildar; Tian, Yong; Mittleman, Guy; Matthews, Douglas B.; Zakharenko, Stanislav S.; Liberman, M. Charles; Zuo, Jian (East Carolina University, 2007-06)The function of the orphan glutamate receptor delta subunits (GluR 1 and GluR 2) remains unclear. GluR 2 is expressed exclusively in the Purkinje cells of the cerebellum, and GluR 1 is prominently expressed in inner ear ... -
Otoconin-90 Deletion Leads to Imbalance but Normal Hearing: A Comparison with Other Otoconia Mutants
Zhao, X.; Jones, Sherri M.; Yamoah, E. N.; Lundberg, Yunxia Wang (East Carolina University, 2008-04)Our sense of gravitation and linear acceleration is mediated by stimulation of vestibular hair cells through displacement of otoconia in the utricle and saccule (the gravity receptor organ). We recently showed that otoconin-90 ... -
A Quantitative Survey of Gravity Receptor Function in Mutant Mouse Strains
Jones, Sherri M.; Johnson, Kenneth R.; Yu, Heping; Erway, Lawrence C.; Alagramam, Kumar N.; Pollak, Natasha; Jones, Timothy A. (East Carolina University, 2005-12)The purpose of this research was to identify vestibular deficits in mice using linear vestibular evoked potentials (VsEPs). VsEP thresholds, peak latencies, and peak amplitudes from 24 strains with known genetic mutations ... -
A targeted Coch missense mutation: a knock-in mouse model for DFNA9 late-onset hearing loss and vestibular dysfunction
Robertson, Nahid G.; Jones, Sherri M.; Sivakumaran, Theru A.; Giersch, Anne B. S.; Jurado, Sara A.; Call, Linda M.; Miller, Constance E.; Maison, Stephane F.; Liberman, M. Charles; Morton, Cynthia C. (East Carolina University, 2008-11-01)Mutations in COCH (coagulation factor C homology) are etiologic for the late-onset, progressive, sensorineural hearing loss and vestibular dysfunction known as DFNA9. We introduced the G88E mutation by gene targeting into ...