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Increased DJ-1 expression under oxidative stress and in Alzheimer's disease brains
(East Carolina University, 2009-02-25)
Mutations in the DJ-1 gene have been linked to autosomal recessive familial Parkinson's disease. To understand the function of DJ-1, we determined the DJ-1 expression in both zebrafish and post mortem human brains. We found ...
Amyloid-beta peptide A beta p3-42 affects early aggregation of full-length A beta 1-42
(East Carolina University, 2009-05)
The major amyloid beta (Aβ) peptides found in the brain of familial and late onset Alzheimer’s
disease include the full-length Aβ1-42 and N-terminally truncated, pyroglutamylated peptides
Aβp3-42 and Aβp11-42. The ...